Neuroprotective effects of Potentilla fulgens on spinal cord injury in rats: an immunohistochemical analysis
Yükleniyor...
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Via Medica
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: This examination was performed to research the advantage of the
antioxidant impact of Potentilla fulgens on spinal cord injury (SCI) in rats.
Materials and methods: In the SCI model of this examination, the tolerably serious
lesion was performed at the L1–L2 spinal segmental level. SCI animals were given
P. fulgens 400 mg/kg/day, intraperitoneally. At 7 days post-lesion, exploratory rats
were executed after intraperitoneal administration 7 ketamine HCL (0.15 mL/100 g
body weight). Spinal cord specimens were taken for histological examination or
assurance of malondialdehyde (MDA) and glutathione (GSH) levels and myeloperoxidase (MPO) action. SCI caused a remarkable decline in spinal cord GSH content,
trailed by noteworthy increments in MDA levels and MPO action.
Results: Degenerative changes in some multipolar and bipolar nerve cells and
pyknotic changes in the nuclei of glial cells were likewise noticed. Remarkable
development was seen in cells and vascular structures of P. fulgens treated groups
when contrasted with untreated groups.
Conclusions: Potentilla fulgens application may influence angiogenetic improvement in vein endothelial cells, reduce inflammatory cell aggregation by influencing cytokine system and may make apoptotic nerve cells and neuroprotective
component in glial cells.
Açıklama
PMD:30402877
Anahtar Kelimeler
Spinal cord injury, Potentilla fulgens, Vascular endothelial growth factor (VEGF), B-cell lymphoma 2 (Bcl-2)
Kaynak
Folia Morphologica
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
78
Sayı
1
Künye
Baloǧlu, M., Çetin, A. ve Tuncer, C. M. (2019). Neuroprotective effects of Potentilla fulgens on spinal cord injury in rats: an immunohistochemical analysis. Folia Morphologica, 78(1), 17-23.
