Neuroprotective effects of Potentilla fulgens on spinal cord injury in rats: an immunohistochemical analysis

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dc.authorid0000-0001-7317-5467en_US
dc.contributor.authorBaloǧlu, Murat
dc.contributor.authorÇetin, Abdurrahman
dc.contributor.authorTuncer, Cudi Mehmet
dc.date.accessioned2022-02-23T10:25:55Z
dc.date.available2022-02-23T10:25:55Z
dc.date.issued2019en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Anatomi Ana Bilim Dalıen_US
dc.descriptionPMD:30402877
dc.description.abstractBackground: This examination was performed to research the advantage of the antioxidant impact of Potentilla fulgens on spinal cord injury (SCI) in rats. Materials and methods: In the SCI model of this examination, the tolerably serious lesion was performed at the L1–L2 spinal segmental level. SCI animals were given P. fulgens 400 mg/kg/day, intraperitoneally. At 7 days post-lesion, exploratory rats were executed after intraperitoneal administration 7 ketamine HCL (0.15 mL/100 g body weight). Spinal cord specimens were taken for histological examination or assurance of malondialdehyde (MDA) and glutathione (GSH) levels and myeloperoxidase (MPO) action. SCI caused a remarkable decline in spinal cord GSH content, trailed by noteworthy increments in MDA levels and MPO action. Results: Degenerative changes in some multipolar and bipolar nerve cells and pyknotic changes in the nuclei of glial cells were likewise noticed. Remarkable development was seen in cells and vascular structures of P. fulgens treated groups when contrasted with untreated groups. Conclusions: Potentilla fulgens application may influence angiogenetic improvement in vein endothelial cells, reduce inflammatory cell aggregation by influencing cytokine system and may make apoptotic nerve cells and neuroprotective component in glial cells.en_US
dc.identifier.citationBaloǧlu, M., Çetin, A. ve Tuncer, C. M. (2019). Neuroprotective effects of Potentilla fulgens on spinal cord injury in rats: an immunohistochemical analysis. Folia Morphologica, 78(1), 17-23.en_US
dc.identifier.doi10.5603/FM.a2018.0050en_US
dc.identifier.endpage23en_US
dc.identifier.issn0015-5659
dc.identifier.issue1en_US
dc.identifier.pmid30402877en_US
dc.identifier.scopus2-s2.0-85062812331en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage17en_US
dc.identifier.urihttps://journals.viamedica.pl/folia_morphologica/article/view/57288
dc.identifier.urihttps://hdl.handle.net/11468/9211
dc.identifier.volume78en_US
dc.identifier.wosWOS:000460026600003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTuncer, Cudi Mehmet
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofFolia Morphologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSpinal cord injuryen_US
dc.subjectPotentilla fulgensen_US
dc.subjectVascular endothelial growth factor (VEGF)en_US
dc.subjectB-cell lymphoma 2 (Bcl-2)en_US
dc.titleNeuroprotective effects of Potentilla fulgens on spinal cord injury in rats: an immunohistochemical analysisen_US
dc.typeArticleen_US

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