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Öğe Heavy Metal Levels and Risk Assessment of Walnut Genotypes (Juglans regia L.) Grown in Aras Basin of Türkiye(Hohere Bundeslehranstalt und Bundesamt fur Wein- und Obstbau Klosterneuburg, 2024) Gülsoy, Ersin; Pehluvan, Mücahit; Şimşek, Uğur; Şanda, Murad Aydın; Şimşek, MiktatWalnuts are among of the most popular nuts worldwide due to their health-promoting compounds, and their consumption is on the rise. This increase in walnut consumption may lead to an increase in the intake of heavy metals in the body. In this study, the levels of the heavy metals Cr, Ni, Pb and Cd were determined in a total of twenty walnut genotypes grown in four different locations in the Aras Basin, and the distribution of these heavy metals according to location was analyzed. While highly significant differences (P<0.001) were found among the walnut genotypes in terms of heavy metal contents, the distribution of these metals among the sites showed differences (P≤0.05). The average amounts of Cr, Ni, Cd and Pb in the walnuts were 476.00 µg kg-1, 202.83 µg kg-1, 2.06 µg kg-1 and 30.64 µg kg-1, respectively. All heavy metals analyzed according to location showed the highest values in Tuzluca. As a result, since the hazard quotient (HQ) which derived from the daily intake rate (DIR) of each trace element analyzed was less than 1 (HQ<1), it was found that the investigated walnut genotypes were not risky for human health. © 2024, Hohere Bundeslehranstalt und Bundesamt fur Wein- und Obstbau Klosterneuburg. All rights reserved.Öğe Modeling of Ti doped CuO/ZnO/AZO thin film solar cell(Nova Science Publishers, Inc., 2024) Candan, Ilhan; Baturay, Silan; Gezgin, Serap Yigit; Kilic, Hamdi SukurThe CuO thin film in the IV group was grown on a glass substrate using a spin coating technique by doping 2% Ti. The optical properties of these films were characterized using ultraviolet-visible (UV-Vis) spectrophotometry. UV-Vis measurements show that the absorption and energy band gap value of Ti: CuO thin films change due to the different crystal structures of the films. Solar cells based on undoped CuO and Tidoped CuO thin films were modeled using the SCAPS-1D simulation program. Depending on the interface defect density, the values of photovoltaic parameters of the solar cells decreased. An increase in the efficiency of the Ti-doped CuO solar cell was observed with the increase in the hole mobility, but it showed lower performance compared to the undoped CuO solar cell. While the undoped CuO solar cell showed quantum efficiency in the narrow visible region close to the UV region, the Ti-doped CuO solar cell contributed to the quantum efficiency in the wider visible region. As a result of the calculations carried out with the simulation program, it was observed that the Ti atom caused a decrease in the efficiency of the CuO solar cell.. © 2024 Nova Science Publishers, Inc. All rights reserved.Öğe Blow up of solutions for a logarithmic Petrovsky equation with variable exponent(Palestine Polytechnic University, 2024) Yılmaz, N.; Pişkin, E.In this article we consider the following a logarithmic Petrovsky equations with variable exponents:(Formula Presented). We proved that under suitable conditions on the initial data, a finite-time blow up result for solutions with negative initial energy. © Palestine Polytechnic University-PPU 2024.Öğe Honokiol Showed Neuroprotective Effects on Cerebellum in Spinal Cord Injury in Rats(Colegio de Farmaceuticos de la Provincia de Buenos Aires, 2024) Ünlü, İlker; Tutal Gürsoy, Görkem; Deveci, EnginSpinal cord injury (SCI) is developed by primarily traumatic external causes or secondarily hemorrhage and edema in cord. SCI causes neurological and multiorgan dysfunction. In the present study, effects of honokiol was investigated on cerebellar tissue in experimental SCI model by biochemical and histochemical analysis. Thirty-male Sprague Dawley rats were assigned to three groups. SCI was developed by dropping a steel rod with a diameter of 3 mm and a weight of 10 g was dropped from 10 cm to the spinal cord T7-9 vertebras under anesthesia. Upon SCI, 50 mg/kg honokiol was intraperitoneally introduced to animals for postoperative 7 days. Cerebellar tissue samples were fixed in zinc-formalin and processed for further histochemical analysis. Blood samples were collected for malondialdehyde (MDA), total antioxidant status (TAS) and oxidant status (TOS). Results were statistically analyzed and recorded. MDA and TOS values were higher and TAS values were lower in SCI compared to sham group. Honokiol restored the values close to values of sham group. Histopathological scores were increased in SCI group but honokiol treatment alleviated the pathologies and restored scores in SCI+honokiol group. IL-6 and Bax expression was mainly negative in sham groups. Glial cells, Purkinje cells and granular cells of cerebellum showed negative IL-6 and Bax immune reaction. SCI increased the expression of IL-6 and Bax in basket cells, Purkinje cells, glia cells of the substantia alba, in ganglions layer. After SCI, honokiol administration reduced the immune reaction of IL-6 and Bax in cerebellar cells and substansia alba. SCI caused hypoxia and tissue degeneration and inflammation in cerebellum. Honokiol administration may prevent cell degeneration and apoptosis by balancing cytokine activity to prevent oxidative stress and may be an alternative in cerebellar therapy. © 2024, Colegio de Farmaceuticos de la Provincia de Buenos Aires. All rights reserved.Öğe The effect of hydrostatic pressure on optoelectronic and thermoelectric properties of materials: Band-gap engineering by DFT(Nova Science Publishers, Inc., 2024) Aliabad, H.A. Rahnamaye; Balci, Gulten KavakIn density functional theory DFT, the determination of accurate band gap of materials by band-gap engineering plays a key role in the prediction of optoelectronic and thermoelectric properties of materials. In a solid, the energy difference between the top of the valence band and the bottom of the conduction band is a band gap where no electron state can exist. Controlling the band gap allows us for the production of highperformance optoelectronic as well as thermoelectric devices. Metals have a zero band gap since there is an overlap between the valence and conduction bands. In a semiconductor, there is a band gap of around 1 eV while the band gap of insulators is much larger than in semiconductors.. © 2024 Nova Science Publishers, Inc. All rights reserved.Öğe Applications of Noor type Differential Operator on Multivalent Functions(Palestine Polytechnic University, 2024) Sakar, F. Müge; Hussain, Saqib; Naeem, Muhammad; Khan, Shahid; Murugusundaramoorthy, Gangadharan; Shareef, ZahidIn current study, we use the definition of convolution (or Hadamard product) and consider the Noor type differential operator to define a new class Ωp (λ, α; Ψ) of multivalent functions in open unit disk. We also give some interesting applications of this operator for multivalent functions by using the method of convolution and derive some useful results. © Palestine Polytechnic University-PPU 2024.Öğe Evaluation of the Effect of Current Herbal Remineralization Agents on Enamel Using Different Methods(Cumhuriyet University Faculty of Dentistry, 2024) Ayaz, Simge Gumus; Bakir, Elif Pinar; Bakir, SeyhmusObjectives: In this study, it was aimed to quantitatively evaluate the remineralization capacity of natural medicaments such as ginger, grape seed extract and rosemary, and materials containing casein and hydroxyapatite of initial caries lesions in vitro. Materials and Methods: 42 enamel samples obtained from human teeth; were divided into six group as; Group-I (10% Casein Phosphopeptide Amorphous Calcium Phosphate [CPP-ACP], GC Tooth Mousse, Group-II (Rosemary Oil), Group-III (ginger+honey), Group-IV (ginger+honey+cocoa), Group-V (grape seed extract) and Group-VI (control group; remineralization solution). After enamel samples were kept in demineralization solution for 72 hours to create initial caries lesion, grouped remineralization agents were applied to enamel samples with caries lesion during the six-day pH cycle. Measurements were made using surface microhardness and DIAGNOdent at three different stages. The data obtained in the research were analyzed using the SPSS 25.0 program. The results were evaluated at the p<0.05 significance level. Results: In surface microhardness measurements, all test materials showed significantly more remineralization than fluoride tooth cream, and grape seed extract was found to be the most successful group (p≤0.05). When all groups were compared with the positive control group, there were significant statistical differences between the groups (p≤0.05). The remineralization capacities of the groups whose activities were examined; grape seed extract> ginger+honey+cocoa>ginger+honey> rosemary oil > GC tooth mousse. Conclusions: It is thought that rosemary, ginger + honey + cocoa, grape seed extract materials can be used for remineralization in these working conditions where the initial caries lesions can be remineralized after six days. © (2024), (Cumhuriyet University Faculty of Dentistry). All rights reserved.Öğe GAMIFICATION AND GAME-BASED LEARNING IN MATHEMATICS EDUCATION FOR ADVANCING SDG 4: A SYSTEMATIC REVIEW AND QUALITATIVE SYNTHESIS OF CONTEMPORARY RESEARCH LITERATURE(Editora Alumni In, 2025) Meylani, RusenObjectives: This study investigates how gamification and game-based learning (GBL) contribute to advancing Sustainable Development Goal 4 (SDG 4) by fostering inclusive, equitable, and high-quality education in mathematics. Theoretical Framework: The research draws on constructivist theories, Self-Determination Theory, and Flow Theory to understand the mechanisms through which educational games enhance learning outcomes. Method: A systematic qualitative synthesis was conducted, analyzing studies published between 2010 and 2023 across databases like ERIC, PsycINFO, and Scopus. Key themes were identified through thematic coding, supported by the CASP qualitative checklist for rigor. Results and Discussion: Findings indicate that gamification improves student engagement, motivation, and achievement. Gamification elements such as points and badges significantly enhance learning experiences. Emerging technologies like VR and AI further amplify the effectiveness of game-based approaches. However, challenges remain in addressing equity in technology access and aligning games with curricula. Research Implications: This review underscores the potential of gamification to support SDG 4 by promoting lifelong learning skills, reducing educational disparities, and fostering inclusivity. Teacher training and policy reforms are critical to scale these approaches effectively. Originality/Value: This research synthesizes contemporary findings to highlight the transformative role of gamification in mathematics education, emphasizing its alignment with the global agenda for sustainable and equitable education. © 2025, Editora Alumni In. All rights reserved.Öğe Iconographical Interpretations of New Figured Composition on The Walls of Diyarbakır(Ataturk Universitesi, 2024) Yariş, SahureDiyarbakır is one of the largest cities in Southeastern Anatolia. The fact that it is on trade routes and is geologically important has paved the way for the city to be used as a permanent settlement throughout history. There are historical artifacts in the city, where many civilizations ruled. The geometric, floral and figurative ornaments engraved on these works reflect the artistic and cultural development of the period in which they were engraved. One of the structures that draws attention with its figurative decorations among these works is the fortification walls surrounding the city. Among the figures engraved on the bastions, gates or wall surfaces, the figure of the eagle, known for its symbols of power, strength and domination, is important. This figure was sometimes made in a single composition and sometimes in a composition. In some signs, the throne is located at the top of the scenes as double-headed and in some signs or doors as single-headed. In the article, in the field studies in 2022-2023, it was tried to introduce the figurative composition that we determined in a rectangular frame on the eastern face of the Inner Castle facing the Tigris Valley, on the left of the Oğrun Gate, on the beginning of the single-line inscription belt on the wall. The fact that the stone in which this composition was processed was worn out paved the way for two different interpretations of the composition. The first is the mother eagle-puppy eagle; the second is the fight scene of the eagle-topped toy bird. In the first comment, it was commented that the mother eagle-puppy eagle could be emphasized and the symbols of compassion and compassion could be processed in the defense structure, and the sultan of the period protected the person appointed as the governor under his own power. In the second, it was stated that the eagle-topped toy bird was the fight scene. With this scene, it was interpreted that the sultan wanted to show his power and strength to his enemies. © 2024, Ataturk Universitesi. All rights reserved.Öğe ECTOPARASITES OF DOMESTIC PIGEONS (Columba livia domestica) IN DIYARBAKIR PROVINCE IN TÜRKIYE(Jomard Publishing, 2024) Ekinci, Ayşe; Sayın İpek, Duygu Neval; İçen, HasanEctoparasitic diseases have been observed in studies that have negative effects, especially on the development of pigeons. This study was conducted to determine the ectoparasite species found in domestic pigeons (Columba livia domestica) in Diyarbakır city center. A total of 125 pigeons in Diyarbakır and its center were studied in terms of ectoparasites. It was determined that 66 (52.8%) of 125 pigeons examined during the study process in Diyarbakır were infested with various ectoparasite species at varying degrees. Columbicola columbae was found in 48% of the pigeons and Goniocotes bidentatus in 4.8%. One species was found in 60 (91%) of the infested pigeons and two species (C. Columbae + G.bidentatus) were found together in 6 (9%) of the infested pigeons. © 2024, Jomard Publishing. All rights reserved.Öğe Ab-initio calculations of structural, electronic, and magnetic properties of Li based heusler compounds(Nova Science Publishers, Inc., 2024) Balci, Gulten Kavak; Ayhan, SeyfettinIn today's technology, the basic properties of these materials must be known to benefit from the material that is produced artificially or exists naturally. The material properties of atoms or molecules can be calculated both experimentally and theoretically. Every new research contributes to improving data and new methods that cost less. Schrodinger equation of the structure of atoms and molecules needs to be resolved to determine the physical properties of these systems. However, for a small number of systems it can be analytically solved and for a few systems numerical solutions can be made. In addition, the Schrodinger equation's analytical or numerical solution is not possible for a many-body system because of electron-electron and electron-core interaction. Therefore, some methods are used to analyze the many-body systems. These methods can be listed as the Wave Functions method, Green's Functions method, and density functional theory (DFT). Here, we will focus on the development of density functional theory. The calculation of the electronic structure of crystal structures is made using computer software packaged programs such as ABINIT, SIESTA, VASP, and Wien2k, which are based on Kohn-Sham equations and Ab-initio methods that enable exact solutions of quantum mechanical ground states of electron systems. In this study, the structural, electronic, and magnetic properties of Libased structures will be determined using the density functional theorybased package program called the Wien2k. © 2024 Nova Science Publishers, Inc. All rights reserved.Öğe Author’s Response(Galenos Publishing House, 2024) Şeker, Erdal; Elçi, Evindar[No abstract available]Öğe Evaluation of parameters predicting in-hospital mortality and septic embolisms in patients with infective endocarditis(Termedia Publishing House Ltd., 2024) Kış, Tuba Tatlı; Kış, Mehmet; Güzel, Tuncay; Mermutluoğlu, ÇiğdemIntroduction: Infective endocarditis (IE) is the infection of the cardiac endothelium and heart valves. The incidence of IE has recently increased due to the widespread use of cardiac device therapies and prosthetic heart valves. Despite modern medical and surgical treatment methods, morbidity and mortality are still high, and it leads to serious complications. Evaluation of predictive factors leading to septic embolism, which is one of the most important complications in terms of mortality and morbidity, is important for improving outcomes in infective endocarditis. Aim: In this study, we aimed to determine the predictive parameters of in-hospital mortality and septic embolism in patients with IE. Material and methods: This was a retrospective cohort study. The patients were divided into two groups: group 1 (septic embolism or mortality +, 21 patients) and group 2 (septic embolism or mortality –, 43 patients). ROC analysis was performed to determine the cut-off value of the predictive parameters. Univariable and multivariable regression analysis was performed to identify parameters significantly associated with in-hospital mortality/septic embolism in infective endocarditis. Results: A total of 64 patients diagnosed with IE were included in the study. In the multivariable regression analysis, the parameters vegetation size (OR = 1.227; 95% CI: 1.019–1.477, p = 0.031), aortic valve vegetation (OR = 0.088; 95% CI: 0.009–0.820, p = 0.033), mitral valve vegetation (OR = 0.082; 95% CI: 0.009–0.760, p = 0.028), albumin (OR = 0.185; 95% CI: 0.039–0.889, p = 0.035) and D-dimer (OR = 1.004; 95% CI: 1.000–1.009, p = 0.045) were found to be independent predictors for septic embolism and mortality in IE patients. Conclusions: Vegetation size, high D-dimer and low serum albumin levels are predictors of in-hospital mortality and septic embolism in patients with IE. © 2024 Termedia Publishing House Ltd.. All rights reserved.Öğe Blueprint for the 21st century online learning environment in stem education through a systematic review and qualitative synthesis(Learning Gate, 2024) Meylani, RuşenThis study explores the critical role of STEM education in equipping students for the challenges of the 21st century and examines the effectiveness of Online Learning Environments (OLEs) in delivering such education. The purpose of this research is to identify the essential characteristics of effective OLEs and provide a comprehensive blueprint for their development. Utilizing a systematic review and qualitative synthesis of 228 peer-reviewed articles published between 2000 and 2023, the study adopts a rigorous methodological approach following PRISMA guidelines to analyze key trends, themes, and actionable insights. Findings reveal 46 essential features of optimal OLEs, categorized into ten themes: future-proofing, brain-based approaches, diverse learning mechanisms, high-fidelity implementation, instructional design perspectives, advanced technologies, online learning objects, pedagogical approaches, psychological considerations, and usability factors. These findings emphasize the integration of innovative technologies and pedagogical strategies to create engaging, inclusive, and adaptive learning environments tailored to diverse learner needs. The study concludes with a comprehensive blueprint designed to guide educators, policymakers, and technology developers in creating OLEs that enhance engagement and learning outcomes in STEM education. Practical implications include actionable recommendations for integrating emerging technologies, fostering professional development, and addressing accessibility challenges to democratize STEM education and prepare learners for the digital economy. © 2024 by the author; licensee Learning Gate.Öğe A Novel Predictor of Vegetation Size in Infective Endocarditis: MAPH Score(Yuzuncu Yil Universitesi Tip Fakultesi, 2024) Mermutluoğlu, Çiğdem; Güzel, Tuncay; Kış, Tuba TatlıThe aim of this study is to evaluate the predictive value of the MAPH score in patients with, a novel score that includes blood viscosity biomarkers such as hematocrit, mean platelet volume (MPV), age, and total protein, on the extent of vegetation in infective endocarditis. This study was retrospective. Fifty-four patients older than 18 years who were diagnosed with infective endocarditis (IE) between June 2017 and June 2023 were inclu ded. The study included patients from three different tertiary healthcare centers. Hematocrit, C-reactive Protein (CRP), MPV, total protein, serum albumin, kidney and liver function tests were analyzed on the first day of hospitalization. The Youden Inde x was used to determine the cut points for predicting age and MPV, hematocrit and total protein values for vegetation size. The MAPH score has been calculated as a total of 0 or 1 point with the cutoff in each ratio, and values above the cut-off were considered 1 point. Thirty-eight patients were found to have large vegetations (>10 mm). The mean age of the patients was 54.78 ± 17.32 years. The other clinical characteristics and demographic data were similar to each other. total protein level, MPV, and MAPH score were significantly higher in the vegetation size >10 mm group than in the vegetation size ≤ 10 mm group when analyzing the clinical laboratory characteristics of the study. The results of our study were that the MAPH score can be used as an estima te of the extent of vegetation cover. © 2024, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.Öğe Anatomical surgical approach to lateral ventricle masses and histopathological findings of the brain(Via Medica, 2024) Ünlü, İlker; Alptekin, Mehmet; Tuncer, Mehmet CudiBackground: The selection of surgical approach to the lateral ventricular masses includes difficulties due to their deep localisations and close proximity to the vascular and the eloquent brain structures. The most appropriate approach that should be chosen in surgical treatment of lateral ventricular masses is still controversial. In this study, the factors in the choice of surgical approach to the lateral ventricle masses and the results of them were investigated. Materials and methods: In this study, 80 patients who underwent surgery in our clinic due to the lateral ventricular masses were retrospectively analysed between the years 2002 and 2013. All the cases were evaluated in terms of clinical and neuroradiological results pre- and postoperatively. In 24 cases the anterior interhemispheric transcallosal, in 4 cases the posterior interhemispheric transcallosal, in 30 cases the posterior interhemispheric precuneal, in 14 cases the transcortical, and in 8 cases the combined surgical approaches were performed. Results: Gender distribution of the cases were 45 male/35 female, and the mean age of them was 31.7 years (7 month — 73 years). In 64 patients the gross total resection was performed, whereas in 16 patients subtotal resection was performed due to the infiltration of eloquent brain areas. In the histopathological examination 52 neuroepithelial, 8 mixed neuroglial, 3 meningeal, 2 lympho-hematopoietic system, 1 pine blastoma, 1 germ cell, 5 metastatic, and 8 other benign masses were observed. After surgery, additional neurological deficits developed in 9 patients. Mortality was observed in 6 patients postoperatively. The average follow-up time was 13 (1–83) months. Conclusions: The essential factors that affect the results of surgical treatment of lateral ventricular masses are the size of the mass, histopathology, location, extension, and the relationship with the neurovascular structures. The goal of surgery is to provide a histopathological diagnosis, gross total resection, if possible, and to normalise the flow of cerebrospinal fluid by eliminating the mass effect of pressure. © 2024 Via Medica.Öğe Superiority of Pathologic Lymph Node Ratio over Positive Lymph Node Count in Operated Early-Stage Breast Cancer(Edizioni Luigi Pozzi, 2024) Urakçı, Zuhat; Ali Kaplan, Muhammet; Oruç, Zeynep; Gümüş, Mahmut; Uncu, Doğan; Ebinç, Senar; Özkan, MetinAIM: In early-stage breast cancer, the axillary lymph nodes play a crucial role in determining the prognosis of the disease. The rate of lymph node involvement might be a more valuable prognostic factor than the number of positive lymph nodes. Therefore, we aimed to evaluate whether the lymph node ratio (LNR) is a superior prognostic indicator compared to the pathologic lymph node count in early-stage disease. METHODS: We included 3053 non-metastatic, lymph node-positive breast cancer patients who were treated and followed at 6 medical oncology centers in Türkiye between 2004–2018. Based on LNR, patients were classified into three risk groups: high (>0.65), intermediate (0.21–0.65), and low (≤0.20). RESULTS: Classification of patients according to the TNM8 system based on the number of positive lymph nodes revealed that pathologic lymph node count (pN)1 accounted for 49.0% (n = 1495), pN2 for 30.0% (n = 917), and pN3 for 21.0% (n = 641). Based on the LNR risk group, the low-risk group accounted for 45.4% (n = 1385), intermediate for 36.2% (n = 1105), and high for 18.4% (n = 563) of the total patients. For the entire patient cohort, the 5-and 10-year disease-free survival (DFS) were 93% and 67%, respectively, while overall survival (OS) rates were 95% and 75%, respectively. The median DFS for patients with N1, N2, and N3 disease was 149 months (94.2–203.7), 120.1 months (108.2–132.0), and 81.8 months (68.4–131.1), respectively (p < 0.001). The median DFS for the three LNR risk groups (low, intermediate, and high risk) was 148.9 months (95.3–202.6), 118.7 months (99.9–137.7), and 81.8 months (68.2– 95.3) respectively. Increasing LNR rate was an independent prognostic factor for DFS, according to multivariate analysis (p < 0.001). Furthermore, the median DFS was 133 months for pathologic N1 patients in the LNR intermediate-high risk group, while the median DFS was not reached in patients with LNR and the pN2 low risk group (p = 0.034). CONCLUSIONS: This study confirms the significance of LNR as a prognostic factor for DFS. The results show that in certain specific subgroups, LNR provides more information than pathologic lymph node counts. © 2024 The Author(s).Öğe HOXA1 expression in placentas of woman with fetal growth restriction(Perinatal Medicine Foundation, 2024) Aydeniz Acar, Gül Ebru; Sevinç Akdeniz, Ayşenur; Türe, Zeynep; Aşır, Ayşegül; Acar, Mesut; Aşır, Fırat; Korak, TuğcanObjective: In this study, we examined the HOXA1 expression in the placentas of women diagnosed with fetal growth restriction (IUGR) by immunoexpression and in silico analysis. Methods: Placenta samples from 40 control (healthy) and 40 pregnant women diagnosed with IUGR were included in the study. The samples were fixed in zinc-formal and embedded in paraffin. Demographic information of the patients was recorded. Sections taken from paraffin blo-cks were analyzed by Hematoxylin-Eosin and HOXA1 immunostaining. The protein-protein interaction network of HOXA1 was constructed using the STRING database and analyzed with Cytoscape. The route description was made with the DAVID web tool. Results: In histopathological examination, intense fibrin accumulation, structural degeneration of placental components, congestion, dilatation and increased syncytial nodes were observed in the IUGR group compared to the control group. HOXA1 gene expression was significantly increased in the IUGR group. The HOXA1 PPI network contained 201 nodes and 3876 edges. MCODE analysis identified 8 modules, the highest scoring module was related to the “Systemic lupus erythematosus”, “Alcoholism” and “Neutrophil extracellular trap formation” pathways. Conclusion: With immunoexpression and in silico analysis, we showed HOXA1 is a player of immune pathways, tissue development, and placental regulation, suggesting potential research avenues in understanding IUGR mechanisms. © 2024 Perinatal Medicine Foundation.Öğe Evaluation of the Regeneration Effects of Systemically Applied Methylprednisolone and Vitamin B12 on Mental Nerve Crush Injury(Turkish Neurosurgical Society, 2024) Kara, Cigdem; Lacin, Nihat; Adak, Berat Metin; Kara, Alper; Tunik, Selcuk; Uysal, Ersin; Soylu, Fahri EmrahAIM: To evaluate the effects of methylprednisolone and vitamin B12 injection on the regeneration of the nerves after a mental nerve crush injury. MATERIAL and METHODS: A total of 40 albino Wistar rats have been randomly divided into four groups: Ynt: ÖNEMLİ: Turkish Neurosurgery_JTN 43470_proof reading group 1 (n=10): crush-like nerve damage was created by pinching the left mental nerve for 60 s with an aneurysm clip and intraperitoneally administered 1 ml of saline for 14 days; group 2 (n=10): the left mental nerve was pinched for 60 s with an aneurysm clip and intraperitoneally administered 2 mg/kg of methylprednisolone for 14 days; group 3, experimental group (n=10): the left mental nerve was pinched for 60 s with an aneurysm clip and intraperitoneally administered 2 mg/kg of vitamin B12 for 14 days; and group 4, experimental group (n=10): the left mental nerve was pinched for 60 s and intraperitoneally administered 2 mg/kg of methylprednisolone and 2 mg/kg of vitamin B12 for 14 days. All rats were sacrificed on the 28th postoperative day, and histopathological evaluation was performed. RESULTS: Nerve damage was higher in the control group than in other groups (p<0.05). When Neural Cell Adhesion Molecule (NCAM) expression levels were compared, no major differences were observed between the methylprednisolone and control groups (p>0.05). The B12 and B12+methylprednisolone groups reached significantly higher NCAM expression levels compared to the control and methylprednisolone groups. When the myelin basic protein (MBP) expression levels were compared (p<0.05), the MBP expression was significantly higher in all experimental groups than in the control group (p<0.05). CONCLUSION: Systemic vitamin B12 and methylprednisolone administration effectively supported remyelination in the crushed mental nerve by increasing Schwann cell proliferation and differentiation. © (2024), (Turkish Neurosurgical Society). All rights reserved.
