Impact of the recovery of left ventricular ejection fraction after TAVI on mortality in patients with aortic stenosis
Yükleniyor...
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
NLM (Medline)
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
OBJECTIVE: To assess the effects of transvalvular aortic valve implantation (TAVI) on the outcomes of the patients with symptomatic severe aortic stenosis (AS), and predict the effect of left ventricular ejection fraction (LVEF) and cardiac structural recovery on mortality after the TAVI in patients with different stage of LV function. METHODS: Out of 191 patients, 151 consecutive patients in 3 centers were evaluated for outcome analysis. Patients were classified into 3 subgroups as AS with reduced ejection fraction (ASrEF) (LVEF <40%), AS with mildly reduced EF (ASmrEF) (LVEF 40-49%) and AS with preserved EF (ASpEF) (LVEF ≥50%). RESULTS: The mean follow-up period was 19.4±12.4 (up to 54) months. All-cause mortality was not different among all 3 groups. (p=0.901). In multivariate analysis, stroke volume index (SVI) (Exp(B): 0.039, 95% confidence interval [CI]: 0.011-0.013, p<0.001), baseline blood urea nitrogen (Exp(B): 1.022, 95% CI: 1.006-1.038, p=0.006), and percent LVEF change after TAVI (d-LVEF) (Exp(B): 0.046, 95% CI: 0.004-0.610, p=0.046) were the independent predictors for mortality after TAVI. The receiver operating characteristic curve analysis showed that the cutoff value of "≤10%" for d-LVEF had sensitivity of 50%, specificity of 75%, and an area under the curve of 0.72 in predicting mortality in patients with SVI <35 mL/m2. CONCLUSION: Improvement of LVEF after TAVI, which reflected the marked LV reverse remodeling, has an impact on the prediction of the survival in patients with AS, and this is more prominent in patients with low SVI.
Açıklama
PMID:34881698
WOS:000732456700003
WOS:000732456700003
Anahtar Kelimeler
Aortic stenosis, Heart failure, Transcatheter aortic valve implantation, Stroke volume index, Ventricular remodeling
Kaynak
Türk Kardiyoloji Derneği Arşivi
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
49
Sayı
8
Künye
Kılıçaslan, B., Ünal, B., Arslan, B., Ekin, T., Özel, E. ve Ertaş, F. (2021). Impact of the recovery of left ventricular ejection fraction after TAVI on mortality in patients with aortic stenosis. Turk Kardiyoloji Dernegi Arşivi, 49(8), 606-614.
