Impact of the recovery of left ventricular ejection fraction after TAVI on mortality in patients with aortic stenosis

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dc.contributor.authorKılıçaslan, Barış
dc.contributor.authorÜnal, Barış
dc.contributor.authorArslan, Bayram
dc.contributor.authorEkin, Tuba
dc.contributor.authorÖzel, Erdem
dc.contributor.authorErtaş, Faruk
dc.contributor.authorDursun, Hüseyin
dc.date.accessioned2022-03-04T10:35:19Z
dc.date.available2022-03-04T10:35:19Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalıen_US
dc.descriptionPMID:34881698
dc.descriptionWOS:000732456700003
dc.description.abstractOBJECTIVE: To assess the effects of transvalvular aortic valve implantation (TAVI) on the outcomes of the patients with symptomatic severe aortic stenosis (AS), and predict the effect of left ventricular ejection fraction (LVEF) and cardiac structural recovery on mortality after the TAVI in patients with different stage of LV function. METHODS: Out of 191 patients, 151 consecutive patients in 3 centers were evaluated for outcome analysis. Patients were classified into 3 subgroups as AS with reduced ejection fraction (ASrEF) (LVEF <40%), AS with mildly reduced EF (ASmrEF) (LVEF 40-49%) and AS with preserved EF (ASpEF) (LVEF ≥50%). RESULTS: The mean follow-up period was 19.4±12.4 (up to 54) months. All-cause mortality was not different among all 3 groups. (p=0.901). In multivariate analysis, stroke volume index (SVI) (Exp(B): 0.039, 95% confidence interval [CI]: 0.011-0.013, p<0.001), baseline blood urea nitrogen (Exp(B): 1.022, 95% CI: 1.006-1.038, p=0.006), and percent LVEF change after TAVI (d-LVEF) (Exp(B): 0.046, 95% CI: 0.004-0.610, p=0.046) were the independent predictors for mortality after TAVI. The receiver operating characteristic curve analysis showed that the cutoff value of "≤10%" for d-LVEF had sensitivity of 50%, specificity of 75%, and an area under the curve of 0.72 in predicting mortality in patients with SVI <35 mL/m2. CONCLUSION: Improvement of LVEF after TAVI, which reflected the marked LV reverse remodeling, has an impact on the prediction of the survival in patients with AS, and this is more prominent in patients with low SVI.en_US
dc.identifier.citationKılıçaslan, B., Ünal, B., Arslan, B., Ekin, T., Özel, E. ve Ertaş, F. (2021). Impact of the recovery of left ventricular ejection fraction after TAVI on mortality in patients with aortic stenosis. Turk Kardiyoloji Dernegi Arşivi, 49(8), 606-614.en_US
dc.identifier.doi10.5543/tkda.2021.66495
dc.identifier.endpage614en_US
dc.identifier.issn1308-4488
dc.identifier.issue8en_US
dc.identifier.pmid34881698
dc.identifier.scopus2-s2.0-85122534174
dc.identifier.scopusqualityQ3
dc.identifier.startpage606en_US
dc.identifier.trdizinid511211
dc.identifier.urihttps://archivestsc.com/jvi.aspx?un=TKDA-66495&volume=49&issue=8
dc.identifier.urihttps://hdl.handle.net/11468/9318
dc.identifier.volume49en_US
dc.identifier.wosWOS:000732456700003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorArslan, Bayram
dc.institutionauthorErtaş, Faruk
dc.language.isoenen_US
dc.publisherNLM (Medline)en_US
dc.relation.ispartofTürk Kardiyoloji Derneği Arşivi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAortic stenosisen_US
dc.subjectHeart failureen_US
dc.subjectTranscatheter aortic valve implantationen_US
dc.subjectStroke volume indexen_US
dc.subjectVentricular remodelingen_US
dc.titleImpact of the recovery of left ventricular ejection fraction after TAVI on mortality in patients with aortic stenosisen_US
dc.titleImpact of the recovery of left ventricular ejection fraction after TAVI on mortality in patients with aortic stenosis
dc.typeArticleen_US

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