Gene polymorphisms of adducin GLY460TRP, ACE I/D, and AGT M235T in pediatric hypertension patients

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dc.authorid0000-0003-2813-1064en_US
dc.authorid0000-0001-6764-8336en_US
dc.contributor.authorKaplan, İbrahim
dc.contributor.authorSancaktar, Enver
dc.contributor.authorEce, Aydın
dc.contributor.authorŞen, Velat
dc.contributor.authorTekkeşin, Nilgün
dc.contributor.authorBaşaralı, Mustafa Kemal
dc.contributor.authorKelekçi, Selvi
dc.contributor.authorEvliyaoğlu, Osman
dc.date.accessioned2023-10-27T13:30:07Z
dc.date.available2023-10-27T13:30:07Z
dc.date.issued2014en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.description.abstractBackground: Hypertension is a major global public health problem that affects both pediatric and adult populations. ACE I/D, AGT M235T, and ADD Gly460Trp polymorphisms are thought to be associated with primary hypertension. In the present study, we examined the frequency of these polymorphisms in a pediatric population with secondary hypertension. Material/Methods: Included in the study were 58 hypertensive and 58 normotensive pediatric patients. ACE I/D and AGT M235T polymorphisms are determined by conventional PCR; ADD Gly460Trp polymorphism was investigated using PCR amplification of genomic DNA. Results: There were significant differences between the control group and pediatric hypertensive group in terms of ACE I/D (P<0.05) and AGT M235T (P[removed]0.05) polymorphism. Conclusions: We suggest that RAS gene polymorphisms (ACE-I/D, AGT M235T) are significantly associated with susceptibility to diseases that lead to secondary hypertension.en_US
dc.identifier.citationKaplan, İ., Sancaktar, E., Aydın, E., Şen, V., Tekkeşin, N., Başaralı, M. K. ve diğerleri. (2014). Gene polymorphisms of adducin GLY460TRP, ACE I/D, and AGT M235T in pediatric hypertension patients. Medical Science Monitor, 20, 1745-1750.en_US
dc.identifier.doi10.12659/MSM.892140
dc.identifier.endpage1750en_US
dc.identifier.issn1234-1010
dc.identifier.pmid25262176
dc.identifier.scopus2-s2.0-84908128458
dc.identifier.scopusqualityQ1
dc.identifier.startpage1745en_US
dc.identifier.urihttps://medscimonit.com/abstract/index/idArt/892140
dc.identifier.urihttps://hdl.handle.net/11468/12986
dc.identifier.volume20en_US
dc.identifier.wosWOS:000342647900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKaplan, İbrahim
dc.institutionauthorAydın, Ece
dc.institutionauthorŞen, Velat
dc.institutionauthorBaşaralı, Mustafa Kemal
dc.institutionauthorKeleçi, Selvi
dc.institutionauthorEvliyaoğlu, Osman
dc.language.isoenen_US
dc.publisherInternational Scientific Literature Inc.en_US
dc.relation.ispartofMedical Science Monitor
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGenesen_US
dc.subjectGeneticen_US
dc.subjectHypertensionen_US
dc.subjectPolymorphismen_US
dc.subjectRasen_US
dc.titleGene polymorphisms of adducin GLY460TRP, ACE I/D, and AGT M235T in pediatric hypertension patientsen_US
dc.titleGene polymorphisms of adducin GLY460TRP, ACE I/D, and AGT M235T in pediatric hypertension patients
dc.typeArticleen_US

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