Gene polymorphisms of adducin GLY460TRP, ACE I/D, and AGT M235T in pediatric hypertension patients
Yükleniyor...
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
International Scientific Literature Inc.
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Hypertension is a major global public health problem that affects both pediatric and adult populations. ACE I/D, AGT M235T, and ADD Gly460Trp polymorphisms are thought to be associated with primary hypertension. In the present study, we examined the frequency of these polymorphisms in a pediatric population with secondary hypertension.
Material/Methods: Included in the study were 58 hypertensive and 58 normotensive pediatric patients. ACE I/D and AGT M235T polymorphisms are determined by conventional PCR; ADD Gly460Trp polymorphism was investigated using PCR amplification of genomic DNA.
Results: There were significant differences between the control group and pediatric hypertensive group in terms of ACE I/D (P<0.05) and AGT M235T (P[removed]0.05) polymorphism.
Conclusions: We suggest that RAS gene polymorphisms (ACE-I/D, AGT M235T) are significantly associated with susceptibility to diseases that lead to secondary hypertension.
Açıklama
Anahtar Kelimeler
Genes, Genetic, Hypertension, Polymorphism, Ras
Kaynak
Medical Science Monitor
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
20
Sayı
Künye
Kaplan, İ., Sancaktar, E., Aydın, E., Şen, V., Tekkeşin, N., Başaralı, M. K. ve diğerleri. (2014). Gene polymorphisms of adducin GLY460TRP, ACE I/D, and AGT M235T in pediatric hypertension patients. Medical Science Monitor, 20, 1745-1750.
