Optical and mechanical clot detection methodologies: A comparison study for routine coagulation testing

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dc.contributor.authorTekkesin, Nilgün
dc.contributor.authorKılınç, Cumhur
dc.date.accessioned2024-02-29T12:57:16Z
dc.date.available2024-02-29T12:57:16Z
dc.date.issued2012en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.description.abstractBackground: Automated coagulation analyzers are preferred to meet increasing coagulation test volume. Two distinct technological families exist based on optical and mechanical clot detection methodologies. Which one is superior to the other is still a conflict and needs new studies. Methods: We have compared prothrombin and activated partial thromboplastin results obtained with mechanical method with those obtained by photo-optical method used routinely in our specialized laboratory. Results: The instrumental results showed good precision ranging between 0.7% and 1.8% coefficient of variation. Statistical analysis demonstrated an excellent correlation between the photo-optical and mechanical analyzers for PT (R2 0.97), and aPTT (R2 0.85). Conclusion: Correlation between the two clot-detection systems was maintained even when measuring turbid samples (R2 ≥ 0.97 for two tests).en_US
dc.identifier.citationTekkesin, N. ve Kılınç, C. (2012). Optical and mechanical clot detection methodologies: A comparison study for routine coagulation testing. Journal of Clinical Laboratory Analysis, 26(3), 125-129.en_US
dc.identifier.doi10.1002/jcla.21497
dc.identifier.endpage129en_US
dc.identifier.issn1098-2825
dc.identifier.issue3en_US
dc.identifier.pmid22628225
dc.identifier.scopus2-s2.0-84861465539
dc.identifier.scopusqualityQ1
dc.identifier.startpage125en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1002/jcla.21497
dc.identifier.urihttps://hdl.handle.net/11468/13444
dc.identifier.volume26en_US
dc.identifier.wosWOS:000304397200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKılınç, Cumhur
dc.language.isoenen_US
dc.relation.ispartofJournal of Clinical Laboratory Analysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBlood coagulationen_US
dc.subjectClot detectionen_US
dc.subjectFactorsen_US
dc.subjectMechanical detectionen_US
dc.subjectOptical detectionen_US
dc.subjectPartial thromboplastin timeen_US
dc.subjectProthrombin timeen_US
dc.titleOptical and mechanical clot detection methodologies: A comparison study for routine coagulation testingen_US
dc.titleOptical and mechanical clot detection methodologies: A comparison study for routine coagulation testing
dc.typeArticleen_US

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