The contribution of postnatal steroid administration to early brain damage in preterm babies with bronchopulmonary dysplasia

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dc.authorid0000-0003-0903-6520en_US
dc.authorid0000-0003-2813-1064en_US
dc.authorid0000-0001-9978-9694en_US
dc.authorid0000-0001-8093-5583en_US
dc.authorid0000-0001-5556-1866en_US
dc.authorid0000-0002-1990-8743en_US
dc.contributor.authorErtuğrul, Sabahattin
dc.contributor.authorDarakci, Savaş Mert
dc.contributor.authorKaplan, İbrahim
dc.contributor.authorYolbaş, İlyas
dc.contributor.authorDeğer, İbrahim
dc.contributor.authorYılmaz, Sibel Tanrıverdi
dc.contributor.authorAktaş, Şerafettin
dc.date.accessioned2022-04-06T12:22:36Z
dc.date.available2022-04-06T12:22:36Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.descriptionPMID: 33819976
dc.description.abstractBackground/aim: Postnatal corticosteroids are commonly used to treat bronchopulmonary dysplasia (BPD). We aimed to show whether S100 calcium-binding B (S100B), neuron-specific enolase (NSE), Tau protein or microtubule-associated protein tau (MAPT), and glial fibrillary acid protein (GFAP) levels would provide any evidence of early neurological damage in premature infants receiving postnatal low dose dexamethasone therapy for BPD treatment. Materials and methods: In this cohort study, 136 preterm infants diagnosed with BPD at ≤32 weeks of gestation formed the study group, and 64 preterm infants formed the control group. NSE, S100B, GFAP, and MAPT levels were first measured before the postnatal corticosteroid treatment in both the patient and the control group on the 28th day and, for a second time, after treatment termination in the patient group. Results: There were significant differences between the measured GFAP, MAPT, and NSE values of the BPD and control groups on the 28th day, whereas there was no significant difference between the measured S100B values of the two groups. There were a statistically significant difference between the NSE values measured on the 28th day and after the treatment within the BPD group, whereas no significant difference existed between the GFAP, MAPT, and S100B values. Conclusion: NSE levels, which indicate brain damage in the early period, increased in preterm babies with BPD who had been administered postnatal dexamethasone.en_US
dc.identifier.citationErtuğrul, S., Darakci, S. M., Kaplan, İ., Yolbaş, İ., Değer, İ., Yılmaz, S. T. ve diğerleri. (2021). The contribution of postnatal steroid administration to early brain damage in preterm babies with bronchopulmonary dysplasia. Turkish Journal of Medical Sciences, 51(4), 1917-1923.en_US
dc.identifier.doi10.3906/sag-2101-295
dc.identifier.endpage1923en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue4en_US
dc.identifier.pmid33819976
dc.identifier.scopus2-s2.0-85114330119
dc.identifier.scopusqualityQ1
dc.identifier.startpage1917en_US
dc.identifier.trdizinid480640
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TkRnd05qUXdNQT09
dc.identifier.urihttps://hdl.handle.net/11468/9549
dc.identifier.volume51en_US
dc.identifier.wosWOS:000691544700042
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorErtuğrul, Sabahattin
dc.institutionauthorDarakci, Savaş Mert
dc.institutionauthorKaplan, İbrahim
dc.institutionauthorYolbaş, İlyas
dc.institutionauthorDeğer, İbrahim
dc.institutionauthorYılmaz, Sibel Tanrıverdi
dc.institutionauthorAktaş, Şerafettin
dc.language.isoenen_US
dc.publisherTÜBİTAKen_US
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBronchopulmonary dysplasiaen_US
dc.subjectNeuron-specific enolaseen_US
dc.subjectMicrotubule-associated proteinsen_US
dc.subjectGlial fibrillary acidic proteinen_US
dc.subjectS100 proteinsen_US
dc.titleThe contribution of postnatal steroid administration to early brain damage in preterm babies with bronchopulmonary dysplasiaen_US
dc.titleThe contribution of postnatal steroid administration to early brain damage in preterm babies with bronchopulmonary dysplasia
dc.typeArticleen_US

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