The contribution of postnatal steroid administration to early brain damage in preterm babies with bronchopulmonary dysplasia
Yükleniyor...
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
TÜBİTAK
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background/aim: Postnatal corticosteroids are commonly used to treat bronchopulmonary dysplasia (BPD). We aimed to show
whether S100 calcium-binding B (S100B), neuron-specific enolase (NSE), Tau protein or microtubule-associated protein tau (MAPT),
and glial fibrillary acid protein (GFAP) levels would provide any evidence of early neurological damage in premature infants receiving
postnatal low dose dexamethasone therapy for BPD treatment.
Materials and methods: In this cohort study, 136 preterm infants diagnosed with BPD at ≤32 weeks of gestation formed the study
group, and 64 preterm infants formed the control group. NSE, S100B, GFAP, and MAPT levels were first measured before the postnatal
corticosteroid treatment in both the patient and the control group on the 28th day and, for a second time, after treatment termination
in the patient group.
Results: There were significant differences between the measured GFAP, MAPT, and NSE values of the BPD and control groups on the
28th day, whereas there was no significant difference between the measured S100B values of the two groups. There were a statistically
significant difference between the NSE values measured on the 28th day and after the treatment within the BPD group, whereas no
significant difference existed between the GFAP, MAPT, and S100B values.
Conclusion: NSE levels, which indicate brain damage in the early period, increased in preterm babies with BPD who had been
administered postnatal dexamethasone.
Açıklama
PMID: 33819976
Anahtar Kelimeler
Bronchopulmonary dysplasia, Neuron-specific enolase, Microtubule-associated proteins, Glial fibrillary acidic protein, S100 proteins
Kaynak
Turkish Journal of Medical Sciences
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
51
Sayı
4
Künye
Ertuğrul, S., Darakci, S. M., Kaplan, İ., Yolbaş, İ., Değer, İ., Yılmaz, S. T. ve diğerleri. (2021). The contribution of postnatal steroid administration to early brain damage in preterm babies with bronchopulmonary dysplasia. Turkish Journal of Medical Sciences, 51(4), 1917-1923.
