Vitamin E protected the mouse adrenal gland against immobilization stress

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dc.authorid0000-0002-6384-9146en_US
dc.contributor.authorAşır, Fırat
dc.contributor.authorNergiz, Yusuf
dc.contributor.authorPala, A.
dc.date.accessioned2024-03-01T08:52:23Z
dc.date.available2024-03-01T08:52:23Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractIn this study, we aimed to investigate the effects of vitamin E on mouse adrenal glands in immobilization stress. Twenty-eight male, 10-week-old, BALB/C mice weighing 30-45 grams were divided into four groups. Mice were placed in a cage where no movement was allowed 6 hours/day for 7 days for immobilization stress. 10 ml/kg vitamin E was administered orogastrically 1 hour before immobilization stress in the vitamin E and stress+vitamin E group. At the end of the 7th day, all the animals were subjected to elevated-plus maze (anxiety) and forced swimming (depression) tests. Left adrenal glands were dissected for routine paraffin tissue embedding protocol. Adrenal sections were stained with hematoxylin-eosin and Azan. Malonaldehyde (MDA) levels were also measured in the adrenal tissues. Anxiety level (0.023), depression level (p=0.042) and MDA values (p=0.01) were significantly increased in the stress group. Histological sections of the stress group showed cortical atrophy, medullary hypertrophy, vascular dilation and hemorrhage. Azan staining revealed a thinned capsule and corticomedullary fibrosis in the stress group. Pathologies induced by immobilization stress were mostly reversed after vitamin E administration. The results suggested that vitamin E alleviates adverse effects of immobilization stress (oxidative, behavioral and histopathologic changes) in mice.en_US
dc.identifier.citationAşır, F., Nergiz, Y. ve Pala, A. (2022). Vitamin E protected the mouse adrenal gland against immobilization stress. Polish Journal of Veterinary Sciences, 25(3), 447-454.en_US
dc.identifier.doi10.24425/pjvs.2022.142029
dc.identifier.endpage454en_US
dc.identifier.issn1505-1773
dc.identifier.issue3en_US
dc.identifier.pmid36155994
dc.identifier.scopus2-s2.0-85138637167
dc.identifier.scopusqualityQ3
dc.identifier.startpage447en_US
dc.identifier.urihttps://journals.pan.pl/dlibra/publication/142029/edition/124382/content
dc.identifier.urihttps://hdl.handle.net/11468/13447
dc.identifier.volume25en_US
dc.identifier.wosWOS:000873288500012
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAşır, Fırat
dc.institutionauthorNergiz, Yusuf
dc.institutionauthorPala, A.
dc.language.isoenen_US
dc.publisherPolska Akademia Nauken_US
dc.relation.ispartofPolish Journal of Veterinary Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectAdrenal glanden_US
dc.subjectImmobilizationen_US
dc.subjectPsychopharmacological testsen_US
dc.subjectStressen_US
dc.subjectVitamin Een_US
dc.titleVitamin E protected the mouse adrenal gland against immobilization stressen_US
dc.titleVitamin E protected the mouse adrenal gland against immobilization stress
dc.typeArticleen_US

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