Long-term monitoring of graves’ disease in children and adolescents: A single-center experience

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dc.contributor.authorTunç, Selma
dc.contributor.authorKöprülü, Özge
dc.contributor.authorOrtaç, Hatice
dc.contributor.authorNalbantoğlu, Özlem
dc.contributor.authorDizdarer, Ceyhun
dc.contributor.authorDemir, Korcan
dc.contributor.authorÖzkan, Behzat
dc.date.accessioned2021-11-03T11:45:26Z
dc.date.available2021-11-03T11:45:26Z
dc.date.issued2019en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik ve Tıbbi Bilişim Ana Bilim Dalıen_US
dc.descriptionPMID:30862149
dc.description.abstractBackground/aim: Graves’ disease (GD) is more severe, requires a more complex treatment, and has a lower probability of achieving remission in children than in adults. There is no consensus on the appropriate duration of antithyroid drug (ATD) treatment. Surgical or radioactive iodine (RAI) treatments are not definitive and generally result in permanent hypothyroidism. This study’s goal was examining the effectiveness of ATD treatment in children and adolescents with GD and determining the risk factors of remission and relapse. Materials and methods: This retrospective study included 45 patients (36 females and 9 males, median age 12.5 years) aged 4–18 who were diagnosed with GD between 2003 and 2017. All patients initially were treated with an ATD. ATD treatment was discontinued at a mean of 23.2 ± 13.2 months (10–37 months). Results: Patients were classified into remission (n = 24) and relapse groups (n = 21). The duration of initial ATD treatment in the remission group was longer (26.91 ± 5.17 months) than in the relapse group (19.09 ± 7.14 months) (P = 0.01). The total ATD treatment duration was statistically longer in the remission group (42.14 ± 14.35 months) than in the relapse group (26.95 ± 16.13 months) (P = 0.03). Conclusion: Long-term initial ATD treatment and long-term total ATD treatment were evaluated as positive parameters for the remission of Graves’ disease in children and adolescents. Our findings showed that the chance of long-term remission increases in direct proportion to the initial ATD treatment duration and the total ATD treatment duration.en_US
dc.identifier.citationTunç, S., Köprülü, Ö., Ortaç, H., Nalbantoğlu, Ö., Dizdarer, C., Demir, K. ve diğerleri. (2019). Long-term monitoring of graves’ disease in children and adolescents: A single-center experience. Turkish Journal of Medical Sciences, 49(2), 464-471.en_US
dc.identifier.doi10.3906/sag-1804-177
dc.identifier.endpage471en_US
dc.identifier.issn1300-0144
dc.identifier.issue2en_US
dc.identifier.pmid30862149
dc.identifier.scopus2-s2.0-85065115604
dc.identifier.scopusqualityQ1
dc.identifier.startpage464en_US
dc.identifier.trdizinid335997
dc.identifier.urihttps://www.scopus.com/search/form.uri?display=basic#basic
dc.identifier.urihttps://hdl.handle.net/11468/8098
dc.identifier.volume49en_US
dc.identifier.wosWOS:000465264700003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorOrtaç, Hatice
dc.language.isoenen_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntithyroid drugsen_US
dc.subjectGraves’ diseaseen_US
dc.subjectHyperthyroidismen_US
dc.titleLong-term monitoring of graves’ disease in children and adolescents: A single-center experienceen_US
dc.titleLong-term monitoring of graves’ disease in children and adolescents: A single-center experience
dc.typeArticleen_US

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