The effect of graft application and allopurinol treatmenon calvarial bone defect in rats

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dc.authorid0000-0002-1967-4844en_US
dc.authorid0000-0001-7317-5467en_US
dc.contributor.advisor
dc.contributor.authorLaçin, Nihat
dc.contributor.authorİzol, Bozan Serhat
dc.contributor.authorÖzkorkmaz, Ebru Gökalp
dc.contributor.authorDeveci, Buşra
dc.contributor.authorTuncer, Cudi Mehmet
dc.date.accessioned2022-02-11T10:50:51Z
dc.date.available2022-02-11T10:50:51Z
dc.date.issued2019en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractPurpose: To investigate the effects of allopurinol administration on osteoinductive reaction and bone development with graft material. Methods: Thirty-six Wistar albino rats were divided into 3 groups. In the control group, calvarial bone defect was only created without any treatment. In the Defect + Graft group, allograft treatment was performed by forming 8 mm calvarial bone defect. In the Defect + Graft + Allopurinol group, alloplastic bone graft was placed in the calvarial bone defect and then, allopurinol (50 mg/kg/day) treatment was intraperitoneally applied for 28 days. Results: Histopathological examination revealed inflammation, congestion in the vessels, and an increase in osteoclast cells in the defect area. We also observed that new osteocyte cells, increase in connective tissue fibers, and new bone trabeculae. Osteopontin expression was positive in osteoblast cells and lacunated osteocyte cells were located in the periphery of the new bone trabeculae. Osteopontin expression was also positive in osteoblasts and osteocytes cells of new bone trabeculae in the graft site. Conclusion: It has been shown that allopurinol treatment in rat calvaria defects may induce osteoblastic activity, matrix development, mature bone cell formation and new bone formation when used with autogenous graftsen_US
dc.identifier.citationLaçin, N., İzol, B. S., Özkorkmaz, E. G., Deveci, B. ve Tuncer, C. M. (2019). The effect of graft application and allopurinol treatmenon calvarial bone defect in rats. Acta Cirurgica Brasileira, 34(3), 201900306.en_US
dc.identifier.doi10.1590/s0102-865020190030000006
dc.identifier.issn0102-8650
dc.identifier.issue3en_US
dc.identifier.pmid30892392
dc.identifier.scopus2-s2.0-85063279800
dc.identifier.scopusqualityQ2
dc.identifier.startpage201900306en_US
dc.identifier.uriscielo.br/j/acb/a/hGQBHgPSXFQpGkSK8vnhLnt/?format=pdf&lang=en
dc.identifier.urihttps://hdl.handle.net/11468/9144
dc.identifier.volume34en_US
dc.identifier.wosWOS:000461476800005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzkorkmaz, Ebru Gökalp
dc.institutionauthorDeveci, Buşra
dc.institutionauthorTuncer, Cudi Mehmet
dc.language.isoenen_US
dc.publisherSociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgiaen_US
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOsteonectinen_US
dc.subjectOsteopontinen_US
dc.subjectAllopurinolen_US
dc.subjectSkullen_US
dc.subjectRatsen_US
dc.titleThe effect of graft application and allopurinol treatmenon calvarial bone defect in ratsen_US
dc.titleThe effect of graft application and allopurinol treatmenon calvarial bone defect in rats
dc.typeArticleen_US

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