The effect of graft application and allopurinol treatmenon calvarial bone defect in rats
Yükleniyor...
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Purpose: To investigate the effects of allopurinol administration on osteoinductive reaction
and bone development with graft material.
Methods: Thirty-six Wistar albino rats were divided into 3 groups. In the control group,
calvarial bone defect was only created without any treatment. In the Defect + Graft group,
allograft treatment was performed by forming 8 mm calvarial bone defect. In the Defect +
Graft + Allopurinol group, alloplastic bone graft was placed in the calvarial bone defect and
then, allopurinol (50 mg/kg/day) treatment was intraperitoneally applied for 28 days.
Results: Histopathological examination revealed inflammation, congestion in the vessels, and
an increase in osteoclast cells in the defect area. We also observed that new osteocyte cells,
increase in connective tissue fibers, and new bone trabeculae. Osteopontin expression was
positive in osteoblast cells and lacunated osteocyte cells were located in the periphery of the
new bone trabeculae. Osteopontin expression was also positive in osteoblasts and osteocytes
cells of new bone trabeculae in the graft site.
Conclusion: It has been shown that allopurinol treatment in rat calvaria defects may induce
osteoblastic activity, matrix development, mature bone cell formation and new bone
formation when used with autogenous grafts
Açıklama
Anahtar Kelimeler
Osteonectin, Osteopontin, Allopurinol, Skull, Rats
Kaynak
Acta Cirurgica Brasileira
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
34
Sayı
3
Künye
Laçin, N., İzol, B. S., Özkorkmaz, E. G., Deveci, B. ve Tuncer, C. M. (2019). The effect of graft application and allopurinol treatmenon calvarial bone defect in rats. Acta Cirurgica Brasileira, 34(3), 201900306.
