The effect of graft application and allopurinol treatmenon calvarial bone defect in rats

Yükleniyor...
Küçük Resim

Tarih

2019

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Purpose: To investigate the effects of allopurinol administration on osteoinductive reaction and bone development with graft material. Methods: Thirty-six Wistar albino rats were divided into 3 groups. In the control group, calvarial bone defect was only created without any treatment. In the Defect + Graft group, allograft treatment was performed by forming 8 mm calvarial bone defect. In the Defect + Graft + Allopurinol group, alloplastic bone graft was placed in the calvarial bone defect and then, allopurinol (50 mg/kg/day) treatment was intraperitoneally applied for 28 days. Results: Histopathological examination revealed inflammation, congestion in the vessels, and an increase in osteoclast cells in the defect area. We also observed that new osteocyte cells, increase in connective tissue fibers, and new bone trabeculae. Osteopontin expression was positive in osteoblast cells and lacunated osteocyte cells were located in the periphery of the new bone trabeculae. Osteopontin expression was also positive in osteoblasts and osteocytes cells of new bone trabeculae in the graft site. Conclusion: It has been shown that allopurinol treatment in rat calvaria defects may induce osteoblastic activity, matrix development, mature bone cell formation and new bone formation when used with autogenous grafts

Açıklama

Anahtar Kelimeler

Osteonectin, Osteopontin, Allopurinol, Skull, Rats

Kaynak

Acta Cirurgica Brasileira

WoS Q Değeri

Q4

Scopus Q Değeri

Q2

Cilt

34

Sayı

3

Künye

Laçin, N., İzol, B. S., Özkorkmaz, E. G., Deveci, B. ve Tuncer, C. M. (2019). The effect of graft application and allopurinol treatmenon calvarial bone defect in rats. Acta Cirurgica Brasileira, 34(3), 201900306.