An evaluation of the effects of caffeic acid phenethyl ester and ankaferd blood stopper on secondary wound healing of oral mucosal tissue

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dc.contributor.authorGül, Mehmet
dc.contributor.authorGünay, Ahmet
dc.contributor.authorTanık, Abdülsamet
dc.date.accessioned2021-09-03T12:42:51Z
dc.date.available2021-09-03T12:42:51Z
dc.date.issued2020en_US
dc.departmentDicle Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji Bölümüen_US
dc.descriptionPMID:31769639
dc.description.abstractBackground/aim: Caffeic acid phenethyl ester (CAPE) and Ankaferd Blood Stopper (ABS) are considered to contribute to wound healing. The purpose of this study was to investigate the effect of ABS and CAPE on secondary wound healing of oral mucosal tissue. Materials and methods: In total, 63 male Sprague-Dawley rats were used in this study. The animals were randomly divided into three groups and anaesthetized with ketamine (8 mg/100 g, intraperitoneally): a control group, CAPE group, and ABS group. A full-thickness excisional wound was created using a 4 mm punch biopsy tool. Topical ABS and CAPE were then applied in each group for 7, 14, and 21 days (n = 7 in each group). The animals in each group were sacrificed after 7, 14, and 21 days. Palatal specimens were stained with haematoxylin-eosin. Vascular endothelial growth factor (VEGF) and tumour necrosis factor-inducible gene 6 (TSG-6) protein expressions were determined using the Western blot method. Results: Inflammation, vessel dilatation, and haemorrhages were significantly lower in the CAPE group as compared with these parameters in the other groups (P < 0.05). Fibrosis was significantly higher in the ABS group as compared with that in the other groups (P < 0.05). VEGF protein levels were elevated in the 21-day CAPE group and 7-day ABS group. The expression of TSG-6 increased in the 7-day CAPE group and 21-day ABS group. Conclusion: Based on our findings, ABS and CAPE had positive effects on the oral wound healing process.en_US
dc.identifier.citationGül, M., Günay, A. ve Tanık, A. (2020). An evaluation of the effects of caffeic acid phenethyl ester and ankaferd blood stopper on secondary wound healing of oral mucosal tissue. Turkish Journal of Medical Sciences, 50(1), 248-257.en_US
dc.identifier.doi10.3906/sag-1908-114
dc.identifier.endpage257en_US
dc.identifier.issn1300-0144
dc.identifier.issue1en_US
dc.identifier.pmid31769639
dc.identifier.scopus2-s2.0-85079345634
dc.identifier.scopusqualityQ1
dc.identifier.startpage248en_US
dc.identifier.trdizinid334306
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/31769639/
dc.identifier.urihttps://hdl.handle.net/11468/7431
dc.identifier.volume50en_US
dc.identifier.wosWOS:000514283600033
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorGünay, Ahmet
dc.language.isoenen_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTumour necrosis factor-inducible gene 6 proteinen_US
dc.subjectVascular endothelial growth factoren_US
dc.subjectWound healingen_US
dc.titleAn evaluation of the effects of caffeic acid phenethyl ester and ankaferd blood stopper on secondary wound healing of oral mucosal tissueen_US
dc.titleAn evaluation of the effects of caffeic acid phenethyl ester and ankaferd blood stopper on secondary wound healing of oral mucosal tissue
dc.typeArticleen_US

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