The association between platelet/lymphocyte ratio and coronary artery disease severity
Yükleniyor...
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Society of Cardiology
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: In this study, we aimed to explore the association between platelet-to-lymphocyte ratio (PLR) and the severity of atherosclerosis in
coronary artery disease (CAD).
Methods: Clinical and laboratory data of 388 patients who underwent coronary angiography were evaluated retrospectively. Gensini score,
which indicates the severity of atherosclerosis, was calculated for all of the patients. Patients with CAD were categorized as mild and severe
atherosclerosis, according to their Gensini score. Eighty patients with normal coronary arteries formed the control group. Mean PLR values of
the three study groups were compared. Also, PLR value was tested for whether it showed a positive correlation with Gensini score.
Results: The mean PLR of the severe atherosclerosis group was significantly higher than that of the mild atherosclerosis and controls groups
(p<0.001). Also, PLR was positively correlated with Gensini score in CAD patients. A cut-off value of 111 for PLR predicted severe atherosclerosis with 61% sensitivity and 59% specificity. Pre-procedural PLR level was found to be independently associated with Gensini score, together
with WBC, age, and low HDL level, in the multivariate analysis.
Conclusion: Our study suggests that high PLR appears to be additive to conventional risk factors and commonly used biomarkers in predicting
severe atherosclerosis. (Anatol J Cardiol 2015; 15: 640-7).
Açıklama
PMID: 25550173
Anahtar Kelimeler
Atherosclerosis, Coronary artery disease, Gensini score, Platelet-lymphocyte ratio
Kaynak
The Anatolian Journal of Cardiology
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
15
Sayı
8
Künye
Yüksel, M., Yıldız, A., Oylumlu, M., Akyüz, A., Aydın, M., Kaya, H. ve diğerleri. (2015). The association between platelet/lymphocyte ratio and coronary artery disease severity. The Anatolian Journal of Cardiology, 15(8), 640-647.
