Comparison of the results of sleeve gastrectomy, gastric pilication and liragulitide in obese rats

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dc.authorid0000-0001-7203-2288en_US
dc.authorid0000-0001-9843-6301en_US
dc.authorid0000-0002-3402-2625en_US
dc.authorid0000-0002-1659-1189en_US
dc.contributor.authorBilge, Hüseyin
dc.contributor.authorBaşol, Ömer
dc.contributor.authorYıldızhan, Eda
dc.contributor.authorÜlger, Burak Veli
dc.contributor.authorTemiz, Hakan
dc.contributor.authorAkkuş, Murat
dc.contributor.authorYıldızhan, I.
dc.date.accessioned2024-03-26T12:18:41Z
dc.date.available2024-03-26T12:18:41Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractObesity, which is generally seen in adults, is a serious health problem. Diseases caused by obesity are among the leading causes of death worldwide. Liraglutide (LG) is an analogue of glucagon-like peptide-1, which slows gastrointestinal motility, resulting in decreased food consumption. Gastric plication (GP) and sleeve gastrectomy (SG) is the reduction of stomach volume by surgical means. We examined and compared the body mass index (BMI) changes, metabolic changes and changes in gastric histology in obese rats after LG injection with surgical methods such as SG and GP. In this research, 35 Wistar Albino female rats were used. Rats were divided into 5 groups with 7 rats in each group. Group (G) 1: The control group, fed with a normal calorie diet for 8 weeks. G 2: Sham group, G 3: SG group, G 4: GP group and G 5: LG group, fed with high-calorie feed for 4 weeks. At the end of the 4th week, the study was terminated by making appropriate interventions for the groups. When the blood glucose (BG) levels measured at the beginning, 4th week and 8th week of the experiment were evaluated, it was monitored that the BG level at the 8th week was the lowest in the LG group (p<0.05). It was observed that the preop Ghrelin and Leptin levels of the LG group were lower than those of the SG and GP groups (p<0.05). As a consequence of our metabolic investigations, we observed that the use of LG is at least as effective as SG.en_US
dc.identifier.citationBilge, H., Başol, Ö., Yıldızhan, E., Ülger, B. V., Temiz, H., Akkuş, M. ve diğerleri. (2023). Comparison of the results of sleeve gastrectomy, gastric pilication and liragulitide in obese rats. Polish Journal of Veterinary Sciences, 26(4), 535-540.en_US
dc.identifier.doi10.24425/pjvs.2023.145059
dc.identifier.endpage540en_US
dc.identifier.issn2300-2557
dc.identifier.issue4en_US
dc.identifier.pmid38088297
dc.identifier.scopus2-s2.0-85179642145
dc.identifier.scopusqualityQ3
dc.identifier.startpage535en_US
dc.identifier.urihttps://journals.pan.pl/dlibra/publication/145059/edition/129567/content
dc.identifier.urihttps://hdl.handle.net/11468/13724
dc.identifier.volume26en_US
dc.identifier.wosWOS:001126693200004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYıldızhan, Eda
dc.institutionauthorÜlger, Burak Veli
dc.institutionauthorTemiz, Hakan
dc.institutionauthorAkkuş, Murat
dc.language.isoenen_US
dc.relation.ispartofPolish Journal of Veterinary Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectObesityen_US
dc.subjectLiraglutideen_US
dc.subjectSleeve gastrectomyen_US
dc.subjectGastric plicationen_US
dc.titleComparison of the results of sleeve gastrectomy, gastric pilication and liragulitide in obese ratsen_US
dc.titleComparison of the results of sleeve gastrectomy, gastric pilication and liragulitide in obese rats
dc.typeArticleen_US

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