Comparison of the results of sleeve gastrectomy, gastric pilication and liragulitide in obese rats
Yükleniyor...
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Obesity, which is generally seen in adults, is a serious health problem. Diseases caused
by obesity are among the leading causes of death worldwide. Liraglutide (LG) is an analogue
of glucagon-like peptide-1, which slows gastrointestinal motility, resulting in decreased food
consumption. Gastric plication (GP) and sleeve gastrectomy (SG) is the reduction of stomach
volume by surgical means. We examined and compared the body mass index (BMI) changes,
metabolic changes and changes in gastric histology in obese rats after LG injection with surgical
methods such as SG and GP.
In this research, 35 Wistar Albino female rats were used. Rats were divided into 5 groups with
7 rats in each group. Group (G) 1: The control group, fed with a normal calorie diet for 8 weeks.
G 2: Sham group, G 3: SG group, G 4: GP group and G 5: LG group, fed with high-calorie feed
for 4 weeks. At the end of the 4th week, the study was terminated by making appropriate interventions for the groups.
When the blood glucose (BG) levels measured at the beginning, 4th week and 8th week
of the experiment were evaluated, it was monitored that the BG level at the 8th week was
the lowest in the LG group (p<0.05). It was observed that the preop Ghrelin and Leptin levels
of the LG group were lower than those of the SG and GP groups (p<0.05).
As a consequence of our metabolic investigations, we observed that the use of LG is at least
as effective as SG.
Açıklama
Anahtar Kelimeler
Obesity, Liraglutide, Sleeve gastrectomy, Gastric plication
Kaynak
Polish Journal of Veterinary Sciences
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
26
Sayı
4
Künye
Bilge, H., Başol, Ö., Yıldızhan, E., Ülger, B. V., Temiz, H., Akkuş, M. ve diğerleri. (2023). Comparison of the results of sleeve gastrectomy, gastric pilication and liragulitide in obese rats. Polish Journal of Veterinary Sciences, 26(4), 535-540.
