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Öğe Akut subdural hematomlu 106 olgunun retrospektif değerlendirilmesi(Dicle Üniversitesi Tıp Fakültesi, 2018) Özevren, Hüseyin; Hattapoğlu, SalihAmaç: ASDH (akut subdural hematom) olgularının klinik bulgularını ve bilgisayarlı tomografi sonuçlarını geriye dönük olarak değerlendirmek. Yöntemler: Ocak 2013 -Mart 2017 yılları arasında kliniğimize başvuran 106 ASDH olgusu geriye dönük olarak incelendi. Her bir olgunun yaş, cinsiyet, subdural hematometiyolojisi, ve BT(bilgisayarlı tomografi) sonuçları değerlendirildi. Olguların beyin BT kesitlerindeki orta hat şifti, hematom hacmi ve dansitesi hesaplanarak incelendi. Sonuçlar istatistiksel olarak değerlendirildi. Bulgular: Beyin cerrahi kliniğine başvuran 106 ASDH olgusunun [80 (%75,5) erkek, 26 (%24,5) kadın], ortalama yaş 37,93±27,16 (1-89) idi. Olguların 65’i (%61,3) kendiliğinden rezorbe oldu. Hastaların 23’ü (%21,7) ameliyat edildi. Bununla beraber olgulardan, 12’si (%11,3) erkek ve 6’sı (%5,6) kadın olmak üzere takiplerimiz esnasında eks olmuştur. Eks olguların kraniyal BT tetkiklerinde orta hat şiftine ek olarak kontüzyon, ödem veya diğer sistemik bulgular mevcuttu. En sık başvuru nedenleri trafik kazaları 48(%45), düşme 23(%22), darp 14(%13), ateşli silah yaralanması 11(%10), spontan kanamalar 10(%10) idi. Erkek ve kadın olgularda; hematom hacmi, dansitesi ve orta hat şifti açısından yapılan istatistiksel karşılaştırmada anlamlı farklılık bulunmadı. Olguların beyin tomografisi incelemesinde ortalama hematom hacimleri 22,54±2,45cm3 (4-120), ortalama subdural hematomdansitesi 52,35±15,12 HU (Hounsfield Units) (18-76), orta hat şifti 2,34±2,99mm (0-17,25) olarak ölçülmüştür. Yaş ile subdural hematom hacmi arasında yapılan korelasyon testi pozitif yönde anlamlı bulundu (p<0,001, r=0,425). Yaş ile hematomdansitesi arasındaki korelasyon testi negatif yönde anlamlı bulundu (p<0,05, r=-0,21). Sonuç: Çalışmamızda, acil polikliniğimize başvuran ASDH’li hastaları etiyolojik, klinik ve radyolojik olarak değerlendirdik. Bu hastalar için kraniyal BT önemli tanı araçıdır. KraniyalBT’deASDH’e ek bulguların olması mortaliteyi önemli ölçüde arttırmaktadır. ASDH’lı hastalarda yaş arttıkça hematom hacmi artmakta ve dansitesi düşmekteydi. Yaşlı hastalarda küçük travmalar sonrasında da ASDH oluşabilmekte ve geç bulgu verebilmektedir.Öğe Analysis of lumbar disc degeneration: 82 cases(İnönü Üniversitesi Tıp Fakültesi, 2019) Özevren, Hüseyin; Çetin, Abdurrahman; Baloğlu, MuratAim: The purpose of this study was to investigate if the grade of lumbar disc degeneration. Intervertebral disc degeneration is a common degenerative disease. Material and Methods: A retrospective analysis on 34 males and 48 females with intervertebral discs degeneration and a mean age of 51.5 years. Using MRI, the grade of lumbar intervertebral discs degeneration was assessed according to the Pfirrmann classification. Results: There was a high correlation (R =0.385) and significant association (pearson correlation, p < 0.01) between L3/L4 disc degeneration and the aging. There was also a high correlation (R =0.56) and significant association (pearson correlation, p <0.001) between the L3/L4 disc degeneration and the L4/L5. Conclusion: For many years, excessive or abnormal mechanical load was thought to be the main cause of disk degeneration. Rates of aging and lumbar disc degeneration have gradually increased over the years. It is important to note that there is a significant relationship between aging and L3 / L4 disc degeneration and that L4 / L5 disc degeneration may also be present in patients with L3 / L4 disc degeneration.Öğe Assessment relationship between the femoral artery vasospasm and dorsal root ganglion cell degeneration in spinal subarachnoid hemorrhage: an experimental study(Springernature, 2022) Çetin, Abdurrahman; Özevren, Hüseyin; Arslan, Remzi; Yektaş, Abdulkadir; Aydın, Mehmet DumluStudy design Animal proof of principle study. Objectives To investigate neurodegeneration in rabbit L4-dorsal root ganglion (DRG) cells by creating experimental spinal subarachnoid hemorrhage (SAH), we aimed to show the neuronal pathway between L-4-DRG and femoral artery. Setting Ataturk University, Medical Faculty, Animal Laboratory, Erzurum, Turkey. Methods This study was designed on 20 rabbits, which were randomly divided into three groups: Spinal SAH (n = 8), SHAM (n = 6), and control (n = 6) groups. Animals were followed for 20 days and then killed. Vasospasm index values of the femoral artery and neuron density of L-4-DRG were analyzed. Results The number of degenerated neurons in DRG was higher in the spinal SAH than the control and SHAM groups (p < 0.001). But, the difference between the control group and the SHAM group was not significant. Normal neuron densities were significantly lower in the spine SAH group compared to the SHAM and the control groups. There was a statistically significant increase in vasospasm index values of the spinal SAH group compared to the other two groups (p < 0.001). Conclusions Decreased volume of the femoral artery lumen was showed in animals with spinal SAH compared with control and SHAM groups. Increased degeneration of the L-4 dorsal root ganglion in animals with spinal SAH was also demonstrated. Our findings might shed light on the planning of future experimental studies and evaluating the clinical relevance of such studies.Öğe Clinical and morphological evaluation of odontoid fractures of C2 vertebra(Society of TURAZ BİLİM, 2020) Çetin, Abdurrahman; Hattapoğlu, Salih; Özevren, HüseyinThere have not been enough studies on cervical vertebra-2 (C2) odontoid fracture and their clinical and radiological evaluation. This study was designed to determinethe proportions of the C2 odontoid fracture types and to determine the specific incidence of fracture types according to age and gender and to evaluate them clinicallyand with cervical spine computed tomography (CT) sections of each case. We retrospectively reviewed 32 cases of C2 odontoid fractures admitted to our clinic betweenJanuary 2013 and March 2017. There were C2 odontoid fracture [15 (46.9%) male and 17 (53.1%) female] who were referred to the neurosurgical clinic. The mean agewas 38.5 (2-87). The most frequent reasons for application were in-vehicle traffic accidents 18 (56.3%), fall 6 (18.8%), outside-vehicle traffic accidents 4 (12.5%), assault3 (9.4%), breast Ca. 1 (3.1%) due to metastasis. In terms of odontoid fracture types; Type I 4 (12.5%), Type II 23 (71.9%), Type III was 5 (15.6%). 13 (40.6%) anterior, 7(21.9%) posterior and 12 (37.5%) nondeplase were applied for odontoid fracture displacement in our cases. Pain and tenderness in the neck region of 29 patients (90.6%)were present in C2 odontoid fractured patients who applied to our clinic, while 3 (9.4%) patients presented with hemiparesia. The Frankel scale of these patients; 1 patient(3.1%) applied with B, 2 (6.3%) with D, 29 (90.6%) with E scale. Odontoid fractures do not always come to us with spinal cord damage, often the initial sign may beonly neck pain. In such cases, odontoid fractures can be easily misdiagnosed and can result in morbidity and mortality, which is a major problem. The aim of our studyis to draw attention to the importance of this issue by evaluating the existing data on odontoid fractures in many aspects, which are not enough studies in the literature.Öğe Conus Medullaris Position in an Adult Population: Analysis of Magnetic Resonance Imaging(Soc Chilena Anatomia, 2016) Karabulut, Özlen; Akay, Hatice; Karabulut, Zülfü; Özevren, Hüseyin; Saka, Günay; Hatipoğlu, Savaş; Deveci, EnginThe objective of this study was to evaluate the variation in position of the conus medullaris (CM) in male and female patients without spinal deformity, to correlate the termination level in magnetic resonance (MR) images of the lumbar spine. 921 patients consisted of 607 men and 314 women were evaluated by MRI. The strength of T1 weighted MRI device was 1.5 Tesla. The patients were in supine position when measured. The termination level of the conus medullaris was recorded in relation to the upper, middle or lower third of the adjacent vertebra and the adjacent intervertebral disc. The patients in our study group were examined for low back pain. The members with spinal deformity were excluded. The distribution of conus medullaris localization was measured to range from T12 to L2-L3. There was a statistically significant difference in the mean conus medullaris position related to gender also a significant difference between increasing age and conus position in female patients. These findings suggest that the distribution of CM location in a large adult population was shown to range from the upper third of T12 to the lower third of L2-L3 disc space both in women and men.Öğe CROSSING LAMINAR SCREW FIXATION OF THE AXIS(2015) Özevren, Hüseyin; Kahveci, Ramazan; Gökçe, Emre CemalC2 çapraz laminar vidalama özellikle pedikül vida fiksasyonu için uygun olmayan anatomiye sahip olgularda kraniyoservikal ve atlantoaksiyel fiksasyon uygulamalarının hem başlangıç hem de kurtarma ameliyatlarında, aynı zamanda C2'nin subaksiyel fiksasyonlara dahil edildiği durumlar için potansiyel olarak güvenli ve etkin bir tekniktir. Bununla birlikte, bireysel bazda vida yerleştirilmesi için laminar anatominin uygunluğunun saptanmasında dikkatli bir ameliyat öncesi radyolojik değerlendirme önemlidir. Bu çalışmadaki amacımız anatomik, radyolojik ve klinik bazda daha önceki literatürü gözden geçirmek ve C2 translaminar vida fiksasyonu için kullanışlı bir klavuz oluşturmaktırÖğe DEGENERATIVE DISC DISEASE AND GENETIC(2015) Karavelioğlu, Ergün; Özevren, Hüseyin; Kahveci, Ramazanİntervertebral disk hastalığının gelişimi her ne kadar multifaktöriyel bir durum olsa da, disk dejenerasyonunda rol oynayan genlerle ilişkili son zamanda yapılan çalışmalar, genetik faktörlerin disk hastalığı gelişimindeki rollerinin önemini ortaya koymuştur. Bu çalışmadaki amacımız intervertebral disk dejenerasyonunda rol oynayan genlerle ilgili mevcut bilgilerin gözden geçirilmesidirÖğe The effect of rosmarinic acid on deformities occurring in brain tissue by craniectomy method. Histopathological evaluation of iba-1 and gfap expressions(Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia, 2020) Özevren, Hüseyin; Deveci, Engin; Tuncer, Cudi MehmetPurpose: To investigate the role of Rosmarinic acid (RA) in the prevention of traumatic brain inand the immunohistochemical analysis of IBA-1 and GFAP expressions.Methods: Healthy male rats were randomly divided into 3 groups consisting of 10 rats. Groups were as follows; control group, traumatic brain injury (TBI) group, and TBI+RA group. After traumatic brain injury, blood samples were taken from the animals and analyzed with various biochemical markers. And then IBA-1 and GFAP expressions were evaluated immunohistochemically.Results: Significant results were obtained in all biochemical parameters between groupImmunohistochemical sections showed IBA-1 not only in microglia and macrophage activity but alsin degenerative neurons in blood vessel endothelial cells. However, GFAP reaction and post-traumatirosmarinic acid administration showed positive expression in astrocytes with regular structure arounthe blood vessel.Conclusion: Rosmarinic acid in blood vessel endothelial cells showed that preserving the integrity of astrocytic structure in the blood brain barrier may be an important antioxidant.Öğe Effects of caffeic acid phenethyl ester on retinal damage after traumatic brain injury(Universidad de la Frontera, 2018) Turgut, Fethiye Gülden; Özevren, Hüseyin; Yıldırım, M.; Deveci, EnginHead trauma damages the optic nerve visual function and visual acuity.Effects of head trauma on the retina was investigated with biochemical, histological and immunohistochemical respects.The study was conducted on 30 rats with three groups: group 1 was control group (n=10). Second group was head-traumatized group (n=10) and last group was head-traumatized+Caffeic acid phenethyl ester (CAPE, i.p. 20ml/kg/day). Upon head was traumatized, CAPE was applied to trauma+CAPE group and then for the following four days. At the end of 5th day, rats were anesthetized with ketamine hydroxide and then blood samples were taken for biochemical analysis. MDA and GSH-Px values were compared. After blood sample, total eyes of rats were dissected for histopathological and immunohistochemical analysis. In trauma group, degeneration in retinal photoreceptor cells, disintegrity and in inner and outer nuclear layers, hypertrophy in ganglion cells, and hemorrhage in blood vessels were observed. In the group treated with CAPE, lesser degeneration in photoreceptor cells, regular appearances of inner and outer nuclear layers, mild hemorrhage in blood vessels of ganglionic cell layer were observed. The apoptotic changes caused by trauma seen in photoreceptor and ganglionic cells were decreased and cellular organization was preserved due to CAPE treatment. CAPE was thought to induce healing process on traumatic damages.Öğe Effects of Potentilla fulgens on the changes made in the retinal damage induced by traumatic head injury(Universidad de la Frontera, 2017) Özevren, Hüseyin; Deveci, EnginTraumatic head injury is a leading cause of mortality and morbidity. As a result of head trauma occurring in the retina of the various biochemical, histological and immunohistochemical effects were investigated. Sprague–Dawley rats were subjected to traumatic brain injury with a weight-drop device using 300 g-1 m weight–height impact. Twenty one rats were divided into three groups, as group 1 (vehicle-treated control), group 2 (vehicle-treated trauma) group 3 trauma + Potentilla fulgens (P. Fulgens) 400 mg/ kg/day, i.p.). Distilled water was used as vehicle. All rats were decapitated 5 days after the induction of trauma, and the protective effects of P. Fulgens were evaluated by histological, immunohistochemical and biochemical analyses. Although further studies are necessary to evaluate the time-and dose-dependent neuroprotective effects of P. Fulgens. Depending on whether trauma inhibits apoptosis of photoreceptor cells, ganglion cells, it is thought that the the support against the degeneration of neural connections can be considered. This study indicates that P.Fulgens is potentially useful for the treatment of eye disorders induced by traumatic brain injury.Öğe Histopathological changes in the choroid plexus after traumatic brain injury in the rats: a histologic and immunohistochemical study(Via Medica, 2018) Özevren, Hüseyin; Deveci, Engin; Tuncer, Mehmet CudiBackground: Traumatic brain injury (TBI) is in part associated with the disruption of the blood-brain barrier. In this study, we analysed the histopathological changes in E-cadherin and vascular endothelial growth factor (VEGF) expression after TBI in rats. Materials and methods: The rats were divided into two groups as the control and the trauma groups. Sprague-Dawley rats were subjected to TBI with a weight-drop device using 300 g/1 m weight-height impact. After 5 days of TBI, blood samples were taken under ketamine hydroxide anaesthesia and biochemical analyses were performed. The control and trauma groups were compared in terms of biochemical values. Results: There was no change in glutathione (GSH) levels and blood-brain barrier permeability. However, malondialdehyde (MDA) and myeloperoxidase (MPO) activity levels increased in the trauma group. In the histopathological examination, choroid plexus in the lateral ventricle, near the pia mater membrane, was removed. In the traumatic group, some of epithelial cells were hyperplasic. Some of them were peeled off the apical surface and had local degeneration. Conclusions: In addition, we observed congestion in capillary vessels and mononuclear cell infiltration around the vessels. After TBI, the increase in VEGF levels, vascular permeability, and interaction with VEGF receptors in endothelial cells lead to oedema of the vessel wall. On the other hand, E-cadherin expression decreased in the tight-junction structures between epithelial cells and basal membrane, resulting in an increase in cerebrospinal fluid in the intervillous area. (Folia Morphol 2018; 77, 4: 642–648)Öğe Immunoexpression of vascular endothelial growth factor, ?-cell lymphoma 2 and cluster of differentiation 68 in cerebellar tissue of rats treated with Ganoderma lucidum(Universidad de la Frontera, 2018) Özevren, Hüseyin; İrtegün, Sevgi; Ekingen, Arzu; Tuncer, Cudi Mehmet; Özkorkmaz, Ebru Gökalp; Deveci, Engin; Deveci, ŞenayTraumatic brain injury (TBI) can potentially lead to hemorrhages in all areas of the skull, which can damage cells andnerve connections. This study aims to investigate the protective effects of Ganoderma lucidum polysaccharides (GLPS) as a antioxidant oncerebellar cell tissues after traumatic brain injury in rats. Sprague Dawley rats were subjected to TBI with a weight-drop device using 300 g-1m weight-height impact. The groups are consisted of control, trauma, and trauma+Ganoderma lucidum groups. At seven days post-braininjury, experimental rats were decapitated after intraperitoneal administration of ketamine HCL (0.15 ml/100 g body weight). Cereballarsamples were taken for histological examination or determination of malondialdehyde (MDA) and glutathione (GSH) levels andmyeloperoxidase (MPO) activity. Significant improvement was observed in cells and vascular structures of Ganoderma lucidum treatedgroups when compared to untreated groups. It is believed that Ganoderma lucidum may have an effect on the progression of traumatic braininjury. Ganoderma lucidum application may affect angiogenetic development in blood vessel endothelial cells, decrease inflammatory cellaccumulation by affecting cytokine mechanism and may create apoptotic nerve cells and neuroprotective mechanism in glial cellsÖğe Kaza ile üzerine cisim düşmesine bağlı hastaneye başvuran hastaların değerlendirilmesi(Dicle Üniversitesi, 2015) Turan, Yahya; Uysal, Cem; Korkmaz, Mustafa; Yılmaz, Tevfik; Göçmez, Cüneyt; Özevren, Hüseyin; Gören, Süleyman; Ceviz, AdnanAmaç: Özellikle çocuklarda olmak üzere ev, iş ve dış ortamlarda meydana gelen kazalar, yaralanma ve ölüm nedenlerinin başında gelmektedir. Bu çalışmada amaç, kaza ile üzerine cisim düşmesine bağlı hastanemize baş- vuran hastaların değerlendirilmesidir. Yöntemler: Bu çalışmamızda kaza ile üzerine cisim düş- mesine bağlı 2012-2014 yılları arasında hastanemize başvuran 135 hastanın dosyaları retrospektif olarak incelendi. Bu hastaların yaş, cinsiyet, olayın nedeni olarak üzerine düşen cismin türü, yeri, zamanı ve ölüm nedenleri analiz edildi. Bulgular: Hastaların 82 ( %60,7)’i erkek, 53 (%39,3)’ü kadın ve yaş ortalaması 18,8 (0-79 yıl) olarak bulundu. En fazla hasta %57,8 (78 hasta) ile çocuk yaş grubunda ( 0-18 yaş) bulunmaktadır. Düşen cismin türü bakımından değerlendirildiğinde sırasıyla %18,5 (25 hasta) ile televizyon, %15,6 (21 hasta) ile taş ve %11,1 (15 hasta) ile demirden yapılmış cisimler ilk üç sırayı paylaşmaktadır. Kazanın meydana geldiği yer olarak ele alındığında en fazla kazanın 85 vaka (%62,9) ile evde olduğu görülmektedir. Kazanın meydana gelme zamanına bakıldığında en fazla 93 vaka (%68,9) ile yaz mevsiminde meydana geldiği görülmektedir. Sonuç: Bu çalışmada elde edilen veriler, özellikle çocukların maruz kaldığı bu tür kazaları önleme programlarına katkı sağlamaktadır.Öğe Morphometric study on the 12th thoracic vertebrae which is most frequently exposed to trauma and the closest vertebra to thoracic aorta(Turkish Association Trauma Emergency Surgery, 2021) Korkmaz, Mehmet Fatih; Özevren, HüseyinBACKGROUND: To describe gender-related differences in the length of the left chord and pedicle at the level of 12th thoracic vertebrae and appropriate length of the screw to be applied so as to decrease the perforation risk of anterior cortex of the corpus and preventable injury of major vascular vessels. METHODS: Axial bone window computed tomography images of T12 vertebral pedicles of 60 patients (30 males and 30 females, age >25 years) without any sign of spinal trauma were obtained and morphometric data were analyzed. RESULTS: Mean ages of the female (n=30) and male (n=30) patients were 32.17 +/- 4.24 and 31.70 +/- 3.60 years, respectively. The left chord lengths of T12 of the male (38.17 +/- 2.54 mm) and female (36.62 +/- 2.27 mm) patients were compared and a statistically significant difference was found between these two measurements (p=0.016). A statistically significant difference between the length of the left chord (37.40 +/- 2.51) (range, 32-44 mm) and age (31.93 +/- 3.91) (range, 25-40 years) and also a moderate degree of correlation were observed (p=0.002), (r=0.401). A statistically significant difference and a moderate degree of correlation were found between the lengths of the left chords (37.40 +/- 2.51; range, 32-44 mm) and the left pedicles (12.12 +/- 1.34; range, 10.0-15.80 mm) (p=0.001), (r=0.577). CONCLUSION: Significant differences and correlations exist between the left pedicle and the left chord in male and female patients and patients with different ages. The data obtained can be used as a guide to determine the implant size and intraoperative management of T12 vertebral pedicle.Öğe Neuroprotective effects of ganoderma lucidum on spinal cord injury(Universidad de la Frontera, 2018) Ekinci, Aysun; Özevren, Hüseyin; Bilgiç, Bülent Emre; Ekinci, Cenap; Deveci, Şenay; Deveci, EnginTraumatic injury to the spinal cord results in the delayed dysfunction and neuronal death. Impaired mitochondrial function, generation of reactive oxygen species (ROS), and lipid peroxidation occur soon after traumatic spinal cord injury (SCI), while the activation of compensatory molecules that neutralize ROS occurs at later time points. The aim of the current study was to investigate the putative neuroprotective effect of Ganoderma lucidum in a rat model of SCI. In order to induce SCI, a standard weight-drop method that induced a moderately severe injury (100 g/cm force) at T10, was used. Injured animals were given either 20 mL/kg Ganoderma lucidum or saline 30 min post injury per day by gastric gavage. At seven days postinjury, rats were decapitated. Spinal cord samples were taken for histological examination or determination of malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity. SCI caused a significant decrease in spinal cord GSH content, which was accompanied with significant increases in MDA levels, MPO activity. On the other hand, Ganoderma lucidum treatment reversed all these biochemical parameters as well as SCI-induced histopathological alterations. Furthermore, impairment of the neurological functions due to SCI was improved by meloxicam treatment. The present study suggests that Ganoderma Lucidum, reduces SCI-induced oxidative stress and exerts neuroprotection by inhibiting lipid peroxidation, GSH depletion.Öğe Posterior epidural migration of a sequestered lumbar intervertebral disc fragment(Turkish Neurosurgical Society, 2017) Turan, Yahya; Yılmaz, Tevfik; Göçmez, Cüneyt; Özevren, Hüseyin; Kemaloğlu, Serdar; Teke, Memik; Sarıyıldız, Mustafa Akif; Ceviz, Adnan; Temiz, CüneytAIm: Posterior epidural migration of a sequestered lumbar intervertebral disc fragment (PEMSLIDF) is an extremely rare condition published so far only as case reports or small case series (ranging between 2 to 8 cases). Diagnosing this condition is often challenging and the diagnosis is usually made intraoperatively. The affected patients usually suffer cauda equina syndrome (CES). In the present study, we aimed to discuss the clinical and radiological findings, types and features of surgical therapies, and outcomes of 9 patients with PEMSLIDF. MaterIal and Methods: This study included 9 (0.36%) patients with PEMSLIDF among 2470 patients who underwent lumbar disc hernia surgery between August 2002 and September 2012. The preoperative clinical and radiological properties of the patients were evaluated. The postoperative outcomes were assessed using neurological examination, radiological imaging, visual analog scale (VAS) and modified Odom criteria. Results: RESULTS: As far as we know, this study is the largest case series examining the characteristics of PEMSLIDF. Seven (77.8%) of our patients were male and 2 (22.2%) were female and they had a mean age of 49.5 years (range 28-70 years). The mean duration from symptom onset to hospital admission was 7.4 days. Seven patients had CES. All patients underwent sequestrectomy and discectomy via posterior microsurgery. The patient outcomes were evaluated by the Modified Odom criteria and the outcome was excellent in two (22.2%) patients, good in 4 (44.5%), fair in 2 (22.2%), and poor in 1 (11.1%). ConclusIon: The entire free fragment can usually be excised via the posterior microsurgery technique. Early surgical treatment is of great importance to prevent more serious neurological deficits.Öğe Posterior Epidural Migration of a Sequestered Lumbar Intervertebral Disc Fragment(2017) Sarıyıldız, Mustafa Akif; Özevren, Hüseyin; Turan, Yahya; Yılmaz, Tevfik; Teke, Memik; Temiz, Cüneyt; Gocmez, CüneytAIm: Posterior epidural migration of a sequestered lumbar intervertebral disc fragment (PEMSLIDF) is an extremely rare condition published so far only as case reports or small case series (ranging between 2 to 8 cases). Diagnosing this condition is often challenging and the diagnosis is usually made intraoperatively. The affected patients usually suffer cauda equina syndrome (CES). In the present study, we aimed to discuss the clinical and radiological findings, types and features of surgical therapies, and outcomes of 9 patients with PEMSLIDF. mATERIAl and mEThODS: This study included 9 (0.36%) patients with PEMSLIDF among 2470 patients who underwent lumbar disc hernia surgery between August 2002 and September 2012. The preoperative clinical and radiological properties of the patients were evaluated. The postoperative outcomes were assessed using neurological examination, radiological imaging, visual analog scale (VAS) and modified Odom criteria. RESUlTS: RESUlTS: As far as we know, this study is the largest case series examining the characteristics of PEMSLIDF. Seven (77.8%) of our patients were male and 2 (22.2%) were female and they had a mean age of 49.5 years (range 28-70 years). The mean duration from symptom onset to hospital admission was 7.4 days. Seven patients had CES. All patients underwent sequestrectomy and discectomy via posterior microsurgery. The patient outcomes were evaluated by the Modified Odom criteria and the outcome was excellent in two (22.2%) patients, good in 4 (44.5%), fair in 2 (22.2%), and poor in 1 (11.1%). CONClUSION: The entire free fragment can usually be excised via the posterior microsurgery technique. Early surgical treatment is of great importance to prevent more serious neurological deficits.Öğe Protective effects of Ganoderma lucidum on the changes made in the retinal damage induced by traumatic head injury(Universidad de la Frontera, 2017) Özevren, Hüseyin; Deveci, EnginHead trauma affects the optic nerve visual function and visual acuity. As a result of head trauma occurring in the retina of the various biochemical, histological and immunohistochemical effects were investigated. The protective effect of Ganoderma lucidum was evaluated on the damage to the retina of the rats. Sprague–Dawley rats were subjected to traumatic brain injury with a weight-drop device using 300 g-1 m weight–height impact. Thirty rats were divided into three groups as group 1 control, 2 group trauma, 3 group trauma+Gonoderma lucidum (20 mL/kg per day via gastric gavage) Ganoderma lucidum was administered for 7 days after trauma.All rats were decapitated 5 days after the induction of trauma, and the protective effects of Ganoderma lucidum in retina were evaluated by histological, immunohistochemical and biochemical analyses. The antioxidant effect of Ganoderma lucidum on the cellular degeneration extracellular matrix and retinal barrier in retina after head trauma was investigated.Öğe TORASİK DİSK HERNİLERİNDE KONSERVATİF TEDAVİ(2014) Korkmaz, Mehmet Fatih; Özdemir, Zeynep Maraş; Yoloğlu, Saim; Kahraman, Bayram; Özevren, Hüseyin; Durak, Mehmet AkifAmaç: Kronik arka ağrısı çeken hastaların ayırıcı tanısında nadir görülen bir sebep olan torasik disk hernilerinin önemini vurgulamak. Materyal ve Metot: Ocak 2010-Eylül 2013 arası polikliniğe sırt ağrısı şikayeti ile başvuran 206 erkek, 231 kadın ortalama 47.98 + 18.41 yaşında (16-88 yaş arası) toplam 437 hastanın epikriz ve radyolojik tetkiklerinin retrospektif olarak incelenmesinden elde edilen sonuçlar değerlendirildi. Cerrahi tedaviyi kabul etmeyen ve konservatif tedavi ile takip ve tedavisi düzenlenen 58 seviye torasik disk hernili 13 erkek, 17 kadın ortalama 51.23 + 17.19 yaşında 30 hasta çalışmaya dâhil edildi.Sonuçlar: Çalışmaya dâhil olan hastaların hiçbirinde T1-2 disk hernisine rastlanmazken, T2-3, T3-4 ve T4-5 diskleri sadece kadın hastalarda görüldü. Tüm torasik disk hernilerinin % 30'unu oluşturan T11-12 disk hernilerinin kadın hastalardaki disk hernilerinin % 47.1'ini erkek hastalardaki disk hernilerinin % 7.7 sini oluşturduğu görüldü, aradaki fark istatistiksel olarak anlamlı idi (p=0.042). Disk dejenerasyonu değerlendirildiğinde grade-3 dejenerasyondan sonra ikinci sıklıkla görülen grade 4 dejenerasyonun kadın hastalarda % 58.8, erkek hastalarda % 15.4 oranında olduğu görüldü, aradaki fark istatistiksel olarak anlamlı idi (p= 0.016).Tartışma: Torasik disk hernisi vakalarının çoğu asemptomatiktir. Eğer spinal kord kompresyonu yoksa hastalığın doğal sürecinde konservatif yönetim savunulur. Tedavi seçeneği konservatif olsa da ilerleyici nörolojik defisit gelişen veya ciddi radiküler ağrısı olan hastalarda cerrahi tedavi gerekmektedirÖğe Vertebral çökme kırıklarında vertebral korpusu çökme derecesinin radyolojik ve biyokimyasal ölçüm parametreleri ile değerlendirilmesi(Harran Üniversitesi Tıp Fakültesi, 2019) Özevren, Hüseyin; Hattapoğlu, Salih; Baloğlu, Murat; Deniz, Muhammed AkifAmaç: Bu çalışmanın amacı, retrospektif olarak çökme kırığı olan hastaların başlangıç ile altıncı ay takiplerindeki radyolojik bulgularını ve kan biyokimyasal değerlerini analiz etmektir. Materyal ve Metod: Haziran 2014 ile Aralık 2018 tarihleri arasında takipli 70torakolomber çökme kırık olgusu retrospektif olarak değerlendirildi. Herhangi bir yaş ve cinsiyet ayrımı yapılmayıp, sadece multipl çökme kırıkları, enfeksiyonlar ve metastazlar çalışma dışında bırakıldı. Radyolojik ve biyokimyasal veriler retrospektif olarak kayıt edildi. İstatistiksel olarak analiz edildi. Bulgular: 70 torakolomber omurga çökme kırık olgusu retrospektif olarak değerlendirildiğinde vakaların 41’i (53,68±19,27) erkek, 29’ı (61,1±16,87) kadındı. Ortalama yaş 56,76±18,56 (14-98) idi. Erkek ve kadınlar arasında erkeklerin sayısı fazla olmakla birlikte, istatistiksel açıdan karşılaştırdığımızda anlamlılık bulunmadı (p=0,09). İleri yaşlarda ise kadınlarda sık görülmekteydi. Torakolomber çökme kırıkları sıklıkla T11-L2 düzeyinde görüldü. Vakaların başlangıç kifoz açıları (10,56±6,97) ile altıncı ay kifoz açıları (12,25±7,47) karşılaştırıldığında, istatistiksel açıdan anlamlı bulundu (p<0.001). Biyokimyasal değerler kendi aralarında pozitif yönde korele iken, yaş ile albumin değerlerinin negatif yönde korele olduğu görüldü. Kifoz açısı ile yaş, biyokimyasal değerler arasında anlamlı korelasyon görülmedi. Sonuç: Çalışmamızda torakolomber omurga çökme kırıklarında zamanla kifoz açısının arttığını gördük. Bu durum yaş ve kan biyokimyasal değerlerinden total protein, albumin, kalsiyum ile ilişkili olmadığı görüldü.
