Immunoexpression of vascular endothelial growth factor, ?-cell lymphoma 2 and cluster of differentiation 68 in cerebellar tissue of rats treated with Ganoderma lucidum
Yükleniyor...
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Universidad de la Frontera
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Traumatic brain injury (TBI) can potentially lead to hemorrhages in all areas of the skull, which can damage cells andnerve connections. This study aims to investigate the protective effects of Ganoderma lucidum polysaccharides (GLPS) as a antioxidant oncerebellar cell tissues after traumatic brain injury in rats. Sprague Dawley rats were subjected to TBI with a weight-drop device using 300 g-1m weight-height impact. The groups are consisted of control, trauma, and trauma+Ganoderma lucidum groups. At seven days post-braininjury, experimental rats were decapitated after intraperitoneal administration of ketamine HCL (0.15 ml/100 g body weight). Cereballarsamples were taken for histological examination or determination of malondialdehyde (MDA) and glutathione (GSH) levels andmyeloperoxidase (MPO) activity. Significant improvement was observed in cells and vascular structures of Ganoderma lucidum treatedgroups when compared to untreated groups. It is believed that Ganoderma lucidum may have an effect on the progression of traumatic braininjury. Ganoderma lucidum application may affect angiogenetic development in blood vessel endothelial cells, decrease inflammatory cellaccumulation by affecting cytokine mechanism and may create apoptotic nerve cells and neuroprotective mechanism in glial cells
Açıklama
Anahtar Kelimeler
βcl-2, CD68, Ganoderma lucidum, Traumatic brain injury, Cerebellum, Histopathology, Rat
Kaynak
International Journal of Morphology
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
36
Sayı
4
Künye
Özevren, H., İrtegün, S., Ekingen, A., Tuncer, C. M., Özkorkmaz, E. G. ve Deveci, E. (2018). Immunoexpression of vascular endothelial growth factor, β-cell lymphoma 2 and cluster of differentiation 68 in cerebellar tissue of rats treated with Ganoderma lucidum. International Journal of Morphology, 36(4), 1453-1462.
