Assessment relationship between the femoral artery vasospasm and dorsal root ganglion cell degeneration in spinal subarachnoid hemorrhage: an experimental study
Yükleniyor...
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springernature
Erişim Hakkı
info:eu-repo/semantics/embargoedAccess
Özet
Study design Animal proof of principle study. Objectives To investigate neurodegeneration in rabbit L4-dorsal root ganglion (DRG) cells by creating experimental spinal subarachnoid hemorrhage (SAH), we aimed to show the neuronal pathway between L-4-DRG and femoral artery. Setting Ataturk University, Medical Faculty, Animal Laboratory, Erzurum, Turkey. Methods This study was designed on 20 rabbits, which were randomly divided into three groups: Spinal SAH (n = 8), SHAM (n = 6), and control (n = 6) groups. Animals were followed for 20 days and then killed. Vasospasm index values of the femoral artery and neuron density of L-4-DRG were analyzed. Results The number of degenerated neurons in DRG was higher in the spinal SAH than the control and SHAM groups (p < 0.001). But, the difference between the control group and the SHAM group was not significant. Normal neuron densities were significantly lower in the spine SAH group compared to the SHAM and the control groups. There was a statistically significant increase in vasospasm index values of the spinal SAH group compared to the other two groups (p < 0.001). Conclusions Decreased volume of the femoral artery lumen was showed in animals with spinal SAH compared with control and SHAM groups. Increased degeneration of the L-4 dorsal root ganglion in animals with spinal SAH was also demonstrated. Our findings might shed light on the planning of future experimental studies and evaluating the clinical relevance of such studies.
Açıklama
WOS:000760019100002
PMID: 35197574
PMID: 35197574
Anahtar Kelimeler
Kaynak
Spinal Cord
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
Early Access
Sayı
Künye
Çetin, A., Özevren, H., Arslan, R., Yektaş, A. ve Aydin, M.D. (2022). Assessment relationship between the femoral artery vasospasm and dorsal root ganglion cell degeneration in spinal subarachnoid hemorrhage: an experimental study, Spinal Cord, Early Access.
