The effect of rosmarinic acid on deformities occurring in brain tissue by craniectomy method. Histopathological evaluation of iba-1 and gfap expressions
Yükleniyor...
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Purpose: To investigate the role of Rosmarinic acid (RA) in the prevention of traumatic brain inand the immunohistochemical analysis of IBA-1 and GFAP expressions.Methods: Healthy male rats were randomly divided into 3 groups consisting of 10 rats. Groups were as follows; control group, traumatic brain injury (TBI) group, and TBI+RA group. After traumatic brain injury, blood samples were taken from the animals and analyzed with various biochemical markers. And then IBA-1 and GFAP expressions were evaluated immunohistochemically.Results: Significant results were obtained in all biochemical parameters between groupImmunohistochemical sections showed IBA-1 not only in microglia and macrophage activity but alsin degenerative neurons in blood vessel endothelial cells. However, GFAP reaction and post-traumatirosmarinic acid administration showed positive expression in astrocytes with regular structure arounthe blood vessel.Conclusion: Rosmarinic acid in blood vessel endothelial cells showed that preserving the integrity of astrocytic structure in the blood brain barrier may be an important antioxidant.
Açıklama
Anahtar Kelimeler
Brain Injuries, Traumatic, Glial fibrillary acidic protein, Rat, Rosmarinic acid
Kaynak
Acta Cirurgica Brasileira
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
35
Sayı
4
Künye
Özevren, H., Deveci, E. ve Tuncer, C. M. (2020). The effect of rosmarinic acid on deformities occurring in brain tissue by craniectomy method. Histopathological evaluation of iba-1 and gfap expressions. Acta Cirurgica Brasileira, 35(4), 1-10.
