Effects of caffeic acid phenethyl ester on retinal damage after traumatic brain injury
Yükleniyor...
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Universidad de la Frontera
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Head trauma damages the optic nerve visual function and visual acuity.Effects of head trauma on the retina was investigated with biochemical, histological and immunohistochemical respects.The study was conducted on 30 rats with three groups: group 1 was control group (n=10). Second group was head-traumatized group (n=10) and last group was head-traumatized+Caffeic acid phenethyl ester (CAPE, i.p. 20ml/kg/day). Upon head was traumatized, CAPE was applied to trauma+CAPE group and then for the following four days. At the end of 5th day, rats were anesthetized with ketamine hydroxide and then blood samples were taken for biochemical analysis. MDA and GSH-Px values were compared. After blood sample, total eyes of rats were dissected for histopathological and immunohistochemical analysis. In trauma group, degeneration in retinal photoreceptor cells, disintegrity and in inner and outer nuclear layers, hypertrophy in ganglion cells, and hemorrhage in blood vessels were observed. In the group treated with CAPE, lesser degeneration in photoreceptor cells, regular appearances of inner and outer nuclear layers, mild hemorrhage in blood vessels of ganglionic cell layer were observed. The apoptotic changes caused by trauma seen in photoreceptor and ganglionic cells were decreased and cellular organization was preserved due to CAPE treatment. CAPE was thought to induce healing process on traumatic damages.
Açıklama
Anahtar Kelimeler
Caffeic Acid Phenethyl Ester (Cape), Rat, Retina, Traumatic Brain İnjury
Kaynak
International Journal of Morphology
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
36
Sayı
1
Künye
Turgut, F. G., Özevren, H., Yıldırım, M. ve Deveci, E. (2018). Effects of caffeic acid phenethyl ester on retinal damage after traumatic brain injury. International Journal of Morphology, 36(1), 97-103.
