The effects of caffeic acid phenethyl ester on inflammatory cytokines after acute spinal cord injury

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dc.contributor.authorAk, Hakan
dc.contributor.authorGulsen, Ismail
dc.contributor.authorKaraaslan, Tamer
dc.contributor.authorAlaca, Ilker
dc.contributor.authorCandan, Aydin
dc.contributor.authorKocak, Havva
dc.contributor.authorAtalay, Tugay
dc.date.accessioned2024-04-24T17:27:46Z
dc.date.available2024-04-24T17:27:46Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractBACKGROUND: The purpose of this study was to investigate the effects of Caffeic Acid Phenethyl Ester (CAPE) on proinflammatory cytokines, IL-1 beta and TNF-alpha, and explore its healing effect after acute spinal cord injury. METHODS: Forty-eight male Wistar-Albino rats were used in this study which was planned as three groups. All groups were divided into two sub-groups. Group la was the control group, in which only lower segment thoracic laminectomy was performed. In group lb, spinal cord trauma was performed with aneurysm clip. In the second group, serum physiologic was given systemically thirty minutes after trauma, and rats were sacrificed after the first and sixth hour. In the third group, CAPE was given systemically thirty minutes after trauma, and rats were sacrificed after the first and sixth hour. Serum IL-1 beta and TNF-alpha levels were analyzed by ELISA in the serum. Histopathological analysis was performed in damaged cord tissues. RESULTS: CAPE suppressed TNF-alpha and IL-1 beta levels in the serum. In histopathological evaluation, it was detected that CAPE decreased hemorrhage and necrosis. CONCLUSION: CAPE suppresses the levels of proinflammatory cytokines, TNF-alpha and IL-1 beta, after acute spinal cord injury in the early phase and contributes to the healing process.en_US
dc.identifier.doi10.5505/tjtes.2015.33848
dc.identifier.endpage101en_US
dc.identifier.issn1306-696X
dc.identifier.issue2en_US
dc.identifier.pmid25904269
dc.identifier.scopus2-s2.0-84924561493
dc.identifier.scopusqualityQ3
dc.identifier.startpage96en_US
dc.identifier.trdizinid197943
dc.identifier.urihttps://doi.org/10.5505/tjtes.2015.33848
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/197943
dc.identifier.urihttps://hdl.handle.net/11468/20184
dc.identifier.volume21en_US
dc.identifier.wosWOS:000351545100003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTurkish Assoc Trauma Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal of Trauma & Emergency Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCapeen_US
dc.subjectIl-1 Betaen_US
dc.subjectInflammationen_US
dc.subjectSpinal Cord Injuryen_US
dc.subjectTnf-Alphaen_US
dc.titleThe effects of caffeic acid phenethyl ester on inflammatory cytokines after acute spinal cord injuryen_US
dc.titleThe effects of caffeic acid phenethyl ester on inflammatory cytokines after acute spinal cord injury
dc.typeArticleen_US

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