Evaluation of serum interleukin-38 levels in different radiographic grades of idiopathic knee osteoarthritis

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dc.authorid0000-0002-3437-5244en_US
dc.authorid0000-0003-2585-9981en_US
dc.authorid0000-0003-4661-9784en_US
dc.contributor.authorDuman, Baver Akcan
dc.contributor.authorDuman, Serda
dc.contributor.authorÇamurcu, Yalkın
dc.contributor.authorGem, Mehmet
dc.contributor.authorErdinç, Levent
dc.date.accessioned2022-12-26T11:27:08Z
dc.date.available2022-12-26T11:27:08Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.description.abstractThe aim of this study was to assess interleukin-1 beta (IL-1 beta), IL-1Ra, IL-36, and IL-38 levels together with hs-CRP levels in patients with different radiographic grades of knee osteoarthritis (OA) in comparison to healthy individuals. Consecutive patients aged over 50 years who were admitted to our Orthopaedics and Traumatology department between November 2018 and March 2019 and diagnosed as knee OA according to the American College of Rheumatology criteria were included in this prospective case-control study. Patients with knee OA were staged according to radiographic Kellgren-Lawrence (K-L) classification and 20 patients were assigned to each group. An age and gender matched control group consisted healthy volunteers with no clinical and radiographic sign of arthritis were conducted as the control group. Venous blood samples were collected and assessed for hs-CRP, IL-1 beta, IL-1Ra, IL-36, and IL-38 levels using the double-antibody sandwich ELISA method. The hs-CRP, IL-1 beta, IL-36 and IL-38 levels did not significantly differ among controls and independent radiographic stage groups except IL-1Ra levels which was significantly higher in K-L grade 4 knee OA groups compared to healthy controls (P = 0.045). When we compared all patients with knee OA and healthy controls, we detected that IL-1 and IL-1Ra were significantly lower and IL-38 levels were significantly higher in healthy control group compared to patients with knee OA (P = < 0.001, < 0.001, and 0.019, respectively). According to results obtained from our study, IL-1 beta, IL-1Ra, and IL-38 levels significantly differed between healthy individuals and patients with knee OA. However, we did not observe a significant difference and correlation between radiographic grade of knee OA and interleukin levels.en_US
dc.identifier.citationDuman, B.A., Duman, S., Çamurcu, Y., Gem, M. ve Erdinç, L. (2021). Evaluation of serum interleukin-38 levels in different radiographic grades of idiopathic knee osteoarthritis. Journal of Interferon and Cytokine Research, 41(11), 425-430.en_US
dc.identifier.doi10.1089/jir.2020.0109
dc.identifier.endpage430en_US
dc.identifier.issn1079-9907
dc.identifier.issn1557-7465
dc.identifier.issue11en_US
dc.identifier.pmid34788133
dc.identifier.scopus2-s2.0-85119879715
dc.identifier.scopusqualityQ3
dc.identifier.startpage425en_US
dc.identifier.urihttps://www.liebertpub.com/doi/full/10.1089/jir.2020.0109
dc.identifier.urihttps://hdl.handle.net/11468/11137
dc.identifier.volume41en_US
dc.identifier.wosWOS:000720070300004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDuman, Baver Akcan
dc.institutionauthorGem, Mehmet
dc.institutionauthorErdinç, Levent
dc.language.isoenen_US
dc.publisherMary Ann Liebert, INCen_US
dc.relation.ispartofJournal of Interferon and Cytokine Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectKnee osteoarthritisen_US
dc.subjectInterleukin-1 betaen_US
dc.subjectInterleukin-1Raen_US
dc.subjectInterleukin-36en_US
dc.subjectInterleukin-38en_US
dc.titleEvaluation of serum interleukin-38 levels in different radiographic grades of idiopathic knee osteoarthritisen_US
dc.titleEvaluation of serum interleukin-38 levels in different radiographic grades of idiopathic knee osteoarthritis
dc.typeArticleen_US

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