Bioguided isolation of secondary metabolites from Salvia cerino-pruinosa Rech. f. var. cerino-pruinosa

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dc.authorid0000-0002-2193-8386en_US
dc.authorid0000-0002-9058-7524en_US
dc.contributor.authorErtaş, Abdulselam
dc.contributor.authorÇakırca, Hatice
dc.contributor.authorYener, İsmail
dc.contributor.authorAkdeniz, Mehmet
dc.contributor.authorFırat, Mehmet
dc.contributor.authorTopçu, Gülaçtı
dc.contributor.authorKolak, Ufuk
dc.date.accessioned2021-07-01T13:24:24Z
dc.date.available2021-07-01T13:24:24Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bililmleri Bölümüen_US
dc.descriptionWOS:000658306500013
dc.description.abstractAbstract: In the current study, the ethanol extracts prepared from the aerial parts and roots of an endemic species, Salvia cerino-pruinosa Rech. f. var. cerino-pruinosa were fractionated on silica gel columns and tested for determination of their antioxidant activity using DPPH free radical and ABTS cation radical scavenging, and cupric reducing antioxidant capacity (CUPRAC) test assays. Twenty known secondary metabolites were isolated from the active antioxidant fractions; rosmarinic acid (1), chlorogenic acid (2), caffeic acid (3), 4- hydroxybenzoic acid (4), benzoic acid (5), luteolin 7-O-glucoside (6), bis-(2-ethylhexyl)benzene-1,2- dicarboxylate (7), salvianolic acid A (8), salvianolic acid B (9), 7-acetylroyleanone (10), 6,7-dehydroroyleanone (11), ferruginol (12), inuroyleanol (13), 12-hydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial (14), ursolic acid (15), oleanolic acid (16), taraxasterol (17), lupenone (18), β-sitosterol (19), and stigmasterol (20). Rosmarinic acid, which was obtained from the aerial parts, was found to be the best antioxidant compound among the isolated secondary metabolites in DPPH free radical and ABTS cation radical scavenging, and CUPRAC assays (IC50: 1.20±0.04 µg/mL, IC50: 1.74±0.06 µg/mL, A0.5: 1.22±0.02 µg/mL, respectively). Chlorogenic and caffeic acids, luteolin 7-O-glucoside, salvianolic acids A and B, and inuroyleanol exhibited also high antioxidant activity in the mentioned assays.en_US
dc.identifier.citationErtaş, A., Çakırca, H., Yener, İ., Akdeniz, M. Fırat, M. Topçu, G. ve diğerleri. (2021). Bioguided isolation of secondary metabolites from Salvia cerino-pruinosa Rech. f. var. cerino-pruinosa. Records of Natural Products, 15(6), 585-592.en_US
dc.identifier.doi10.25135/rnp.248.21.01.1933
dc.identifier.endpage592en_US
dc.identifier.issn1307-6167
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85108605390
dc.identifier.scopusqualityQ2
dc.identifier.startpage585en_US
dc.identifier.trdizinidTRDizinIdYok
dc.identifier.urihttps://www.acgpubs.org/doc/20210529191350A12-248-RNP-2101-1933.pdf
dc.identifier.urihttps://hdl.handle.net/11468/7195
dc.identifier.volume15en_US
dc.identifier.wosWOS:000658306500013
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorErtaş, Abdulselam
dc.institutionauthorÇakırca, Hatice
dc.language.isoenen_US
dc.publisherACG Publicationsen_US
dc.relation.ispartofRecords of Natural Products
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSalvia cerino-pruinosaen_US
dc.subjectIsolationen_US
dc.subjectSecondary metaboliteen_US
dc.subjectAntioxidanten_US
dc.titleBioguided isolation of secondary metabolites from Salvia cerino-pruinosa Rech. f. var. cerino-pruinosaen_US
dc.titleBioguided isolation of secondary metabolites from Salvia cerino-pruinosa Rech. f. var. cerino-pruinosa
dc.typeArticleen_US

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