Bioguided isolation of secondary metabolites from Salvia cerino-pruinosa Rech. f. var. cerino-pruinosa
Yükleniyor...
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ACG Publications
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Abstract: In the current study, the ethanol extracts prepared from the aerial parts and roots of an endemic
species, Salvia cerino-pruinosa Rech. f. var. cerino-pruinosa were fractionated on silica gel columns and tested
for determination of their antioxidant activity using DPPH free radical and ABTS cation radical scavenging, and
cupric reducing antioxidant capacity (CUPRAC) test assays. Twenty known secondary metabolites were isolated
from the active antioxidant fractions; rosmarinic acid (1), chlorogenic acid (2), caffeic acid (3), 4-
hydroxybenzoic acid (4), benzoic acid (5), luteolin 7-O-glucoside (6), bis-(2-ethylhexyl)benzene-1,2-
dicarboxylate (7), salvianolic acid A (8), salvianolic acid B (9), 7-acetylroyleanone (10), 6,7-dehydroroyleanone
(11), ferruginol (12), inuroyleanol (13), 12-hydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial (14), ursolic acid
(15), oleanolic acid (16), taraxasterol (17), lupenone (18), β-sitosterol (19), and stigmasterol (20). Rosmarinic
acid, which was obtained from the aerial parts, was found to be the best antioxidant compound among the
isolated secondary metabolites in DPPH free radical and ABTS cation radical scavenging, and CUPRAC assays
(IC50: 1.20±0.04 µg/mL, IC50: 1.74±0.06 µg/mL, A0.5: 1.22±0.02 µg/mL, respectively). Chlorogenic and caffeic
acids, luteolin 7-O-glucoside, salvianolic acids A and B, and inuroyleanol exhibited also high antioxidant
activity in the mentioned assays.
Açıklama
WOS:000658306500013
Anahtar Kelimeler
Salvia cerino-pruinosa, Isolation, Secondary metabolite, Antioxidant
Kaynak
Records of Natural Products
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
15
Sayı
6
Künye
Ertaş, A., Çakırca, H., Yener, İ., Akdeniz, M. Fırat, M. Topçu, G. ve diğerleri. (2021). Bioguided isolation of secondary metabolites from Salvia cerino-pruinosa Rech. f. var. cerino-pruinosa. Records of Natural Products, 15(6), 585-592.
