Adverse effects of metamizole on heart, lung, liver, kidney, and stomach in rats

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dc.contributor.authorÇiftel, Sedat
dc.contributor.authorSüleyman, Bahadır
dc.contributor.authorMammadov, Renad
dc.contributor.authorCoşkun, Reşit
dc.contributor.authorÇoban, Taha Abdülkadir
dc.contributor.authorMokhtare, Behzad
dc.contributor.authorSüleyman, Hali̇s
dc.date.accessioned2024-09-02T13:14:57Z
dc.date.available2024-09-02T13:14:57Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Veteriner Fakültesi, Klinik Öncesi Bilimler Bölümü, Patoloji Ana Bilim Dalıen_US
dc.description.abstractBackground: Metamizole is banned in some countries because of its toxicity, although it is widely used in some European countries. In addition, there is limited information on its safety profile, and it is still debated whether it is toxic to the heart, lungs, liver, kidneys, and stomach. Aims: Our study investigated the effects of metamizole on the heart, lung, liver, kidney, and stomach tissues of rats. Methods: Eighteen rats were divided into three groups, wassix healthy (HG), 500 mg/kg metamizole (MT-500), and 1000 mg/kg metamizole (MT-1000). Metamizole was administered orally twice daily for 14 days. Meanwhile, the HG group received pure water orally. Biochemical, histopathologic, and macroscopic examinations were performed on blood samples and tissues. Results: Malondialdehyde (MDA), total glutathione (tGSH), superoxide dismutase (SOD), and catalase (CAT) in the lung and gastric tissues of MT-500 and MT-1000 groups were almost the same as those of the HG (p > 0.05). However, MDA levels in the heart and liver tissues of MT-500 and MT-1000 groups were higher (p < 0.05) compared to the HG, while tGSH levels and SOD, and CAT activities were lower (p < 0.05). MDA levels of MT-500 and MT-1000 groups in the kidney tissue increased the most (p < 0.001), and tGSH levels and SOD and CAT activities decreased the most (p < 0.001) compared to HG. Metamizole did not cause oxidative damage in the lung and gastric tissue. While metamizole did not change troponin levels, it significantly increased alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), and creatinine levels compared to HG. Histopathologically, mild damage was detected in heart tissue, moderate damage in liver tissue, and severe damage in renal tissue. However, no histopathologic damage was found in any groups’ lung and gastric tissues. Conclusion: Metamizole should be used under strict control in patients with cardiac and liver diseases and it would be more appropriate not to use it in patients with renal disease.en_US
dc.identifier.citationÇiftel, S., Süleyman, B., Mammadov, R., Coşkun, R., Çoban, T. A., Mokhtare, B. ve diğerleri. (2024). Adverse effects of metamizole on heart, lung, liver, kidney, and stomach in rats. BMC Pharmacology and Toxicology, 25(1), 1-11.en_US
dc.identifier.endpage11en_US
dc.identifier.issn2050-6511
dc.identifier.issue1en_US
dc.identifier.pmid39175070
dc.identifier.scopus2-s2.0-85201812198
dc.identifier.scopusqualityQ2
dc.identifier.startpage1en_US
dc.identifier.urihttps://bmcpharmacoltoxicol.biomedcentral.com/articles/10.1186/s40360-024-00780-4
dc.identifier.urihttps://hdl.handle.net/11468/28810
dc.identifier.volume25en_US
dc.identifier.wosWOS:001296563700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorMokhtare, Behzad
dc.language.isoenen_US
dc.publisherBioMed Central Ltden_US
dc.relation.ispartofBMC Pharmacology and Toxicology
dc.relation.isversionof10.1186/s40360-024-00780-4en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHearten_US
dc.subjectKidneyen_US
dc.subjectLiveren_US
dc.subjectLungen_US
dc.subjectMetamizoleen_US
dc.subjectOxidative damageen_US
dc.subjectStomachen_US
dc.titleAdverse effects of metamizole on heart, lung, liver, kidney, and stomach in ratsen_US
dc.titleAdverse effects of metamizole on heart, lung, liver, kidney, and stomach in rats
dc.typeArticleen_US

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