Cytogenetic screening in couples with Habitual Abortions

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dc.contributor.authorSak, Sibel
dc.contributor.authorIncebiyik, Adnan
dc.contributor.authorHilali, Nese Gul
dc.contributor.authorAgacayak, Elif
dc.contributor.authorUyanikoglu, Hacer
dc.contributor.authorAkbas, Halit
dc.contributor.authorSak, Muhammet Erdal
dc.date.accessioned2024-04-24T16:15:13Z
dc.date.available2024-04-24T16:15:13Z
dc.date.issued2019
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Habitual abortion (HA) is defined at least three consecutive pregnancy losses. One of the etiologic causes is parental chromosomal anomalies. In this study, we aimed to that investigate the effect of parental chromosomal abnormalities on HA. Methods: The cytogenetic results of patients with at least three abortions referred to our university hospital between January 2010 - March 2017 were evaluated. A total of 1154 couples with HA were analysed. Peripheral lymphocyte cultures incubated for 72 h were used for karyotype analysis via the Giemsa banding technique. Results: Of a total 1154 couples (2308 patients) 37 female (3.2%) and 17 male (1.47%) had abnormal karyotypes. Reciprocal translocation carriage (n = 26; 1.12%) was the most commonly detected structural anomaly, followed by X chromosome mosaicism (n = 16; 0.69%), Robertsoniantransiocation (n = 9; 0.38%), Chromosomal inversion (n = 6; 0.26%). Chromosomal polymorphisms, which are considered minor chromosomal changes, were detected in 221 (9.57%) individuals. Conclusion: Our study exhibits that chromosomal analysis in patient with HA is an appropriate approach to elucidate the aetiology of HA. Data from cytogenetic screening can be used in guiding couples planning future pregnancies and in prenatal diagnosis of chromosomal anomalies in the foetus. (C) 2018 Published by Elsevier Masson SAS.en_US
dc.identifier.doi10.1016/j.jogoh.2018.10.021
dc.identifier.endpage158en_US
dc.identifier.issn2468-7847
dc.identifier.issn1773-0430
dc.identifier.issue3en_US
dc.identifier.pmid30412789
dc.identifier.scopus2-s2.0-85056308209
dc.identifier.scopusqualityQ2
dc.identifier.startpage155en_US
dc.identifier.urihttps://doi.org/10.1016/j.jogoh.2018.10.021
dc.identifier.urihttps://hdl.handle.net/11468/15707
dc.identifier.volume48en_US
dc.identifier.wosWOS:000467002200004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Masson, Corporation Officeen_US
dc.relation.ispartofJournal of Gynecology Obstetrics and Human Reproduction
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChromosomal Anomalyen_US
dc.subjectCytogenetic Analysisen_US
dc.subjectHabitual Abortionsen_US
dc.titleCytogenetic screening in couples with Habitual Abortionsen_US
dc.titleCytogenetic screening in couples with Habitual Abortions
dc.typeArticleen_US

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