Evaluation of kidney function tests in HIV-positive patients receiving combined antiretroviral therapy

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dc.authorid0000-0001-7657-3065en_US
dc.authorid0000-0002-8101-2497en_US
dc.authorid0000-0003-2419-3436en_US
dc.authorid0000-0001-5424-5714en_US
dc.contributor.authorAydın, Emre E.
dc.contributor.authorAydın, Fatma Yılmaz
dc.contributor.authorDemir, Yakup
dc.contributor.authorYıldırım, Yaşar
dc.contributor.authorÇelen, Mustafa Kemal
dc.date.accessioned2022-03-18T11:02:31Z
dc.date.available2022-03-18T11:02:31Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalıen_US
dc.descriptionPMID: 34137140
dc.descriptionWOS:000667245000001
dc.description.abstractIntroduction: Human immunodeficiency virus is a chronic infection that attacks the immune system of the human body, particularly CD4 T lymphocytes. Combined antiretroviral therapies are highly effective in virological suppression of human immunodeficiency virus infection. It has been shown that some retroviral therapies have a higher nephrotoxicity potential. As a result of renal injury, serum creatinine increases and the estimated glomerular filtration rate is reduced. The aim of our study was to assess changes in kidney function during a 24-month period in HIV-positive patients who were begun on combined antiretroviral therapy. Material and Methods: A total of 127 HIV-positive patients were enrolled. The patients were divided into five groups; patients who received no therapy were designated as group 1; those who received Dolutegravir/Abacavir/Lamivudine combination as group 2; those who received Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide Fumarate combination as group 3; those who received Emtricitabine/Tenofovir Disoproxil Fumarate/Dolutegravir combination as group 4; and those who received Emtricitabine/Tenofovir Disoproxil Fumarate/Raltegravir combination as group 5. We compared the effects of these drugs on estimated glomerular filtration rate during a 24-month follow-up period. Results: At the 24th month of therapy, a significant difference was observed between the estimated glomerular filtration rate (eGFR) levels of the study groups (P <.001). eGFR level was significantly higher in group 4 compared with groups 1, 2 and 3 (P =.009, P <.001, P <.001, respectively), whereas it was significantly lower in group 5 than groups 1, 2 and 3 (P =.005, P <.001, P [removed].05). Serum creatinine level was significantly higher in groups 4 and 5 compared with the other groups (P <.001). Conclusion: The use of TDF-containing regimens causes renal dysfunction. Therefore, we recommend close monitoring of renal function, especially in patients treated with TDF.en_US
dc.identifier.citationAydın, E. E., Aydın, F. Y., Demir, Y., Yıldırım, Y. ve Çelen, M. K. (2021). Evaluation of kidney function tests in HIV-positive patients receiving combined antiretroviral therapy. International Journal of Clinical Practice, 75(8), e14542.en_US
dc.identifier.doi10.1111/ijcp.14542
dc.identifier.issn1368-5031
dc.identifier.issue8en_US
dc.identifier.pmid34137140
dc.identifier.scopus2-s2.0-85110891974
dc.identifier.scopusqualityQ1
dc.identifier.startpagee14542en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1111/ijcp.14542
dc.identifier.urihttps://hdl.handle.net/11468/9456
dc.identifier.volume75en_US
dc.identifier.wosWOS:000667245000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAydın, Emre E.
dc.institutionauthorAydın, Fatma Yılmaz
dc.institutionauthorDemir, Yakup
dc.institutionauthorYıldırım, Yaşar
dc.institutionauthorÇelen, Mustafa Kemal
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofInternational Journal of Clinical Practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdenineen_US
dc.subjectAnti-HIV Agentsen_US
dc.subjectEmtricitabineen_US
dc.subjectHIV Infectionsen_US
dc.subjectHIV-1en_US
dc.subjectHumansen_US
dc.subjectKidney Function Testsen_US
dc.subjectTenofoviren_US
dc.titleEvaluation of kidney function tests in HIV-positive patients receiving combined antiretroviral therapyen_US
dc.titleEvaluation of kidney function tests in HIV-positive patients receiving combined antiretroviral therapy
dc.typeArticleen_US

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