Evaluation of kidney function tests in HIV-positive patients receiving combined antiretroviral therapy
Yükleniyor...
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
John Wiley and Sons Inc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Introduction: Human immunodeficiency virus is a chronic infection that attacks the immune system of the human body, particularly CD4 T lymphocytes. Combined antiretroviral therapies are highly effective in virological suppression of human immunodeficiency virus infection. It has been shown that some retroviral therapies have a higher nephrotoxicity potential. As a result of renal injury, serum creatinine increases and the estimated glomerular filtration rate is reduced. The aim of our study was to assess changes in kidney function during a 24-month period in HIV-positive patients who were begun on combined antiretroviral therapy. Material and Methods: A total of 127 HIV-positive patients were enrolled. The patients were divided into five groups; patients who received no therapy were designated as group 1; those who received Dolutegravir/Abacavir/Lamivudine combination as group 2; those who received Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide Fumarate combination as group 3; those who received Emtricitabine/Tenofovir Disoproxil Fumarate/Dolutegravir combination as group 4; and those who received Emtricitabine/Tenofovir Disoproxil Fumarate/Raltegravir combination as group 5. We compared the effects of these drugs on estimated glomerular filtration rate during a 24-month follow-up period. Results: At the 24th month of therapy, a significant difference was observed between the estimated glomerular filtration rate (eGFR) levels of the study groups (P <.001). eGFR level was significantly higher in group 4 compared with groups 1, 2 and 3 (P =.009, P <.001, P <.001, respectively), whereas it was significantly lower in group 5 than groups 1, 2 and 3 (P =.005, P <.001, P [removed].05). Serum creatinine level was significantly higher in groups 4 and 5 compared with the other groups (P <.001). Conclusion: The use of TDF-containing regimens causes renal dysfunction. Therefore, we recommend close monitoring of renal function, especially in patients treated with TDF.
Açıklama
PMID: 34137140
WOS:000667245000001
WOS:000667245000001
Anahtar Kelimeler
Adenine, Anti-HIV Agents, Emtricitabine, HIV Infections, HIV-1, Humans, Kidney Function Tests, Tenofovir
Kaynak
International Journal of Clinical Practice
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
75
Sayı
8
Künye
Aydın, E. E., Aydın, F. Y., Demir, Y., Yıldırım, Y. ve Çelen, M. K. (2021). Evaluation of kidney function tests in HIV-positive patients receiving combined antiretroviral therapy. International Journal of Clinical Practice, 75(8), e14542.
