The effect of hyperbaric oxygen therapy on fracture healing in nicotinized rats

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dc.contributor.authorDemirtas, Abdullah
dc.contributor.authorAzboy, Ibrahim
dc.contributor.authorBulut, Mehmet
dc.contributor.authorUcar, Bekir Yavuz
dc.contributor.authorAlemdar, Celil
dc.contributor.authorAlabalik, Ulas
dc.contributor.authorAkpolat, Veysi
dc.date.accessioned2024-04-24T17:27:46Z
dc.date.available2024-04-24T17:27:46Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractBACKGROUND: The aim of the present study was to investigate the effect of hyperbaric oxygen therapy on fracture healing in nicotinized rats. METHODS: Thirty-two rats were divided as follows: nicotinized group (1), hyperbaric oxygen group (2), nicotinized + hyperbaric oxygen group (3), and control group (4). For 28 days, nicotine was administered in Groups 1 and 3. Then, a standard shaft fracture was induced in the left femur of rats. Groups 2 and 3 underwent hyperbaric oxygen therapy for 21 days. At the end of the experiment, fracture site, left femur and whole body bone mineral content and density were measured. RESULTS: The radiological and histopathological scores of Group 1 were statistically significantly lower compared to Groups 2, 3 and 4, and there was no statistically significant difference between the Groups 2, 3 and 4. In a comparison between the groups, no statistically significant difference was found in terms of bone mineral content and density values measured at the fracture site, left femur and whole body. CONCLUSION: The negative effects of nicotine on fracture healing are eliminated with hyperbaric oxygen therapy, but hyperbaric oxygen alone does not cause significant changes in healing (radiologically and histopathologically).en_US
dc.identifier.doi10.5505/tjtes.2014.52323
dc.identifier.endpage166en_US
dc.identifier.issn1306-696X
dc.identifier.issue3en_US
dc.identifier.pmid24936836
dc.identifier.scopus2-s2.0-84901670737
dc.identifier.scopusqualityQ3
dc.identifier.startpage161en_US
dc.identifier.trdizinid227485
dc.identifier.urihttps://doi.org/10.5505/tjtes.2014.52323
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/227485
dc.identifier.urihttps://hdl.handle.net/11468/20182
dc.identifier.volume20en_US
dc.identifier.wosWOS:000337163600002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTurkish Assoc Trauma Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal of Trauma & Emergency Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFracture Healingen_US
dc.subjectHyperbaric Oxygenen_US
dc.subjectNicotineen_US
dc.titleThe effect of hyperbaric oxygen therapy on fracture healing in nicotinized ratsen_US
dc.titleThe effect of hyperbaric oxygen therapy on fracture healing in nicotinized rats
dc.typeArticleen_US

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