Resolution of (±)-?-Methylphenylethylamine by a Novel Chiral Stationary Phase for Pirkle-Type Column Chromatography
Yükleniyor...
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, a new Pirkle-type chiral column stationary phase for resolution of beta-methylphenylethyl amine was described by using activated Sepharose 4B as a matrix, L-tyrosine as a spacer arm, and an aromatic amine derivative of L-glutamic acid as a ligand. The binding capacities of the stationary phase were determined at different pH values (pH = 6, 7, and 8) using buffer solutions as mobile phase, and enantiomeric excess (ee) was determined by HPLC equipped with chiral column. The ee was found to be 47%. Chirality 22:252-257, 2010. (C) 2009 Wiley-Liss, Inc.
Açıklama
Anahtar Kelimeler
Sepharose 4b, Resolution, Chiral amines, Hplc, Pirkle-type column chromatography
Kaynak
Chirality
WoS Q Değeri
Q1
Scopus Q Değeri
Q2
Cilt
22
Sayı
2
Künye
Yılmaz, H., Topal, G., Çakmak, R. ve Hoşgören, H. (2010). Resolution of (±)-β-methylphenylethylamine by a novel chiral stationary phase for Pirkle-type column chromatography. Chirality, 22(2), 252-257.
