Resolution of (±)-?-Methylphenylethylamine by a Novel Chiral Stationary Phase for Pirkle-Type Column Chromatography

Yükleniyor...
Küçük Resim

Tarih

2010

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Wiley

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

In this study, a new Pirkle-type chiral column stationary phase for resolution of beta-methylphenylethyl amine was described by using activated Sepharose 4B as a matrix, L-tyrosine as a spacer arm, and an aromatic amine derivative of L-glutamic acid as a ligand. The binding capacities of the stationary phase were determined at different pH values (pH = 6, 7, and 8) using buffer solutions as mobile phase, and enantiomeric excess (ee) was determined by HPLC equipped with chiral column. The ee was found to be 47%. Chirality 22:252-257, 2010. (C) 2009 Wiley-Liss, Inc.

Açıklama

Anahtar Kelimeler

Sepharose 4b, Resolution, Chiral amines, Hplc, Pirkle-type column chromatography

Kaynak

Chirality

WoS Q Değeri

Q1

Scopus Q Değeri

Q2

Cilt

22

Sayı

2

Künye

Yılmaz, H., Topal, G., Çakmak, R. ve Hoşgören, H. (2010). Resolution of (±)-β-methylphenylethylamine by a novel chiral stationary phase for Pirkle-type column chromatography. Chirality, 22(2), 252-257.