MicroRNAs expression profiles as biomarkers and therapeutic tools in Turkish patients with chronic myeloid leukemia

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dc.contributor.authorYurt, Y.
dc.contributor.authorAyyıldız, Orhan
dc.contributor.authorKarakuş, A.
dc.contributor.authorNursal, Ayşe Feyda
dc.contributor.authorİsi, Hilmi
dc.date.accessioned2021-09-03T08:20:31Z
dc.date.available2021-09-03T08:20:31Z
dc.date.issued2020en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalıen_US
dc.descriptionPMID:32115971
dc.description.abstractAIM: In 95 % of Chronic myeloid leukemia (CML) patients, chromosomal translocation resulting in the formation of the Philadelphia (Ph) chromosome (t:9;22) is observed, which in turn leads to the formation of the BCR-ABL fusion gene. MicroRNAs (miRNAs) are a group of small and non-coding RNAs modulating gene expression via binding to the target mRNAs. We aimed to characterize the expression profiles of various miRNAs in different stages of Ph(+) CML patients. METHODS: This case-controlled study was conducted in 75 CML patients and 25 healthy controls. The subjects were categorized into 4 groups; newly diagnosed patients, treatment-response patients, treatment-failure patients, and healthy controls. Expressions of miRNAs was analyzed by RT-PCR. RESULTS: miR-150 expression was downregulated in the treatment failure patients compared to the control group (p = 0.003212) while miRNA 148b expression up-regulated in the treatment failure patients than the control group (p = 0.038016). miR-10a expression was up-regulated in newly diagnosed and treatment response patients compared to control group (p = 0.003934, p = 0.000292, respectively). It was found that miR-10a expression increased 11.17- fold in newly diagnosed patients and 9.82-fold in treatment response patients than in the control group. CONCLUSION: Our data suggest that expression profiles of miR-10a, miR-150, and miRNA 148b were correlated as biomarker and therapeutic tool in Turkish patients with CML (Tab. 2, Fig. 1, Ref. 30). Text in PDF www.elis.sk.en_US
dc.identifier.citationYurt, Y., Ayyıldız, O., A, K., Nursal, A. F. ve İsi, H. (2020). MicroRNAs expression profiles as biomarkers and therapeutic tools in Turkish patients with chronic myeloid leukemia. Bratislava Medical Journal, 121(2), 159-163.en_US
dc.identifier.doi10.4149/BLL_2020_023en_US
dc.identifier.endpage163en_US
dc.identifier.issn0006-9248
dc.identifier.issue2en_US
dc.identifier.pmid32115971en_US
dc.identifier.scopus2-s2.0-85080840430en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage159en_US
dc.identifier.urihttp://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=6534&category_id=158&option=com_virtuemart
dc.identifier.urihttps://hdl.handle.net/11468/7429
dc.identifier.volume121en_US
dc.identifier.wosWOS:000508930100011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYurt, Y.
dc.institutionauthorAyyıldız, Orhan
dc.institutionauthorA, Karakus
dc.institutionauthorIsi, Hilmi
dc.language.isoenen_US
dc.publisherComenius University in Bratislavaen_US
dc.relation.ispartofBratislava Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChronic myeloid leukemiaen_US
dc.subjectMicroRNAsen_US
dc.subjectNew diagnosisen_US
dc.subjectTreatment failureen_US
dc.subjectTreatment responseen_US
dc.titleMicroRNAs expression profiles as biomarkers and therapeutic tools in Turkish patients with chronic myeloid leukemiaen_US
dc.typeArticleen_US

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