A novel predictor in patients undergoing heart valve surgery: systemic inflammation response index: a single center cross-sectional study

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dc.contributor.authorKaracalilar, M.
dc.contributor.authorDemir, M.
dc.date.accessioned2024-04-24T17:33:11Z
dc.date.available2024-04-24T17:33:11Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: Inflammation plays a pivotal role in heart valve disease (HVD). This study aimed at evaluating the prognostic value of systemic inflammation response index (SIRI) after valve replacement surgery.SUBJECTS AND METHODS: The study en-rolled 90 patients who underwent valve replace-ment surgery. SIRI was calculated using labo-ratory data on admission. Receiver operating characteristic (ROC) analysis was used to calcu-late the optimal cutoff values of SIRI for predict-ing mortality. Univariable and multivariable COX analysis was used to assess the relationship of SIRI with clinical outcomes.RESULTS: 5-year mortality rate was high-er in SIRI >= 1.55 group than SIRI <1.55 group [16 (38.1%) vs. 9 (18.8%)]. In receiver operating char-acteristic analysis, the optimal cutoff values for SIRI were 1.55 (area under the curve 0.654, p: 0.025). Univariable analysis revealed that SIRI [OR: 1.41, 95%CI (1.13-1.75), p<0.001] was an in-dependent predictor of 5-years mortality. Multi -variable analysis revealed that glomerular filtra-tion rate (GFR) [OR: 0.98, 95%CI (0.97-0.99)] was an independent predictor of 5-years mortality.CONCLUSIONS: Although SIRI is a preferable parameter for the detection of long-term mortali-ty, it failed to predict in-hospital and 1-year mor-tality. Larger multi-center studies are needed to investigate effect of SIRI on prognosis.en_US
dc.identifier.endpage1022en_US
dc.identifier.issn1128-3602
dc.identifier.issue3en_US
dc.identifier.pmid36808347
dc.identifier.scopus2-s2.0-85148678353
dc.identifier.scopusqualityQ2
dc.identifier.startpage1016en_US
dc.identifier.urihttps://hdl.handle.net/11468/20510
dc.identifier.volume27en_US
dc.identifier.wosWOS:000951507500023
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiac Valve Prosthesesen_US
dc.subjectPrognosisen_US
dc.subjectInflammationen_US
dc.subjectHeart Valve Prosthesis Implantationen_US
dc.titleA novel predictor in patients undergoing heart valve surgery: systemic inflammation response index: a single center cross-sectional studyen_US
dc.titleA novel predictor in patients undergoing heart valve surgery: systemic inflammation response index: a single center cross-sectional study
dc.typeArticleen_US

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