A novel predictor in patients undergoing heart valve surgery: systemic inflammation response index: a single center cross-sectional study

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Tarih

2023

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Verduci Publisher

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

OBJECTIVE: Inflammation plays a pivotal role in heart valve disease (HVD). This study aimed at evaluating the prognostic value of systemic inflammation response index (SIRI) after valve replacement surgery.SUBJECTS AND METHODS: The study en-rolled 90 patients who underwent valve replace-ment surgery. SIRI was calculated using labo-ratory data on admission. Receiver operating characteristic (ROC) analysis was used to calcu-late the optimal cutoff values of SIRI for predict-ing mortality. Univariable and multivariable COX analysis was used to assess the relationship of SIRI with clinical outcomes.RESULTS: 5-year mortality rate was high-er in SIRI >= 1.55 group than SIRI <1.55 group [16 (38.1%) vs. 9 (18.8%)]. In receiver operating char-acteristic analysis, the optimal cutoff values for SIRI were 1.55 (area under the curve 0.654, p: 0.025). Univariable analysis revealed that SIRI [OR: 1.41, 95%CI (1.13-1.75), p<0.001] was an in-dependent predictor of 5-years mortality. Multi -variable analysis revealed that glomerular filtra-tion rate (GFR) [OR: 0.98, 95%CI (0.97-0.99)] was an independent predictor of 5-years mortality.CONCLUSIONS: Although SIRI is a preferable parameter for the detection of long-term mortali-ty, it failed to predict in-hospital and 1-year mor-tality. Larger multi-center studies are needed to investigate effect of SIRI on prognosis.

Açıklama

Anahtar Kelimeler

Cardiac Valve Prostheses, Prognosis, Inflammation, Heart Valve Prosthesis Implantation

Kaynak

European Review For Medical and Pharmacological Sciences

WoS Q Değeri

N/A

Scopus Q Değeri

Q2

Cilt

27

Sayı

3

Künye