A novel predictor in patients undergoing heart valve surgery: systemic inflammation response index: a single center cross-sectional study
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Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Verduci Publisher
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
OBJECTIVE: Inflammation plays a pivotal role in heart valve disease (HVD). This study aimed at evaluating the prognostic value of systemic inflammation response index (SIRI) after valve replacement surgery.SUBJECTS AND METHODS: The study en-rolled 90 patients who underwent valve replace-ment surgery. SIRI was calculated using labo-ratory data on admission. Receiver operating characteristic (ROC) analysis was used to calcu-late the optimal cutoff values of SIRI for predict-ing mortality. Univariable and multivariable COX analysis was used to assess the relationship of SIRI with clinical outcomes.RESULTS: 5-year mortality rate was high-er in SIRI >= 1.55 group than SIRI <1.55 group [16 (38.1%) vs. 9 (18.8%)]. In receiver operating char-acteristic analysis, the optimal cutoff values for SIRI were 1.55 (area under the curve 0.654, p: 0.025). Univariable analysis revealed that SIRI [OR: 1.41, 95%CI (1.13-1.75), p<0.001] was an in-dependent predictor of 5-years mortality. Multi -variable analysis revealed that glomerular filtra-tion rate (GFR) [OR: 0.98, 95%CI (0.97-0.99)] was an independent predictor of 5-years mortality.CONCLUSIONS: Although SIRI is a preferable parameter for the detection of long-term mortali-ty, it failed to predict in-hospital and 1-year mor-tality. Larger multi-center studies are needed to investigate effect of SIRI on prognosis.
Açıklama
Anahtar Kelimeler
Cardiac Valve Prostheses, Prognosis, Inflammation, Heart Valve Prosthesis Implantation
Kaynak
European Review For Medical and Pharmacological Sciences
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
27
Sayı
3
