Routine enzymes in the monitoring of type 2 diabetes mellitus

Basit Öğe Kaydı
dc.contributor.authorEvliyaoğlu, Osman
dc.contributor.authorKıbrıslı, Erkan
dc.contributor.authorYıldırım, Yaşar
dc.contributor.authorGökalp, Osman
dc.contributor.authorÇolpan, Leyla
dc.date.accessioned2024-04-24T15:59:22Z
dc.date.available2024-04-24T15:59:22Z
dc.date.issued2011
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.description.abstractWe examined the relationships of glucose and HbA1c levels with the routinely screened serum enzyme activities in type 2 diabetes mellitus, and we designed an in vitro study to evaluate the direct effect of glucose levels on enzyme activities. The study was performed on a consecutive series of outpatients with type 2 diabetes who were followed up at Dicle University Medical Faculty Hospital from May 2009 to May 2010 for the first time. Effects of aspartate transaminase, aminotransferase, gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) activities, glucose and HbA1c levels and in vitro glucose (492, 287, 184, 131, 82 mg dl(-1), respectively) on enzymes were determined. The patients were categorized on the basis of glucose and HbA1c levels and grouped according to a range of values. In patients with high HbA1c levels (>10.1%), ALP, GGT activities and creatine kinase (CK)-MB/CK (p = 0.008, 0.026, 0.014) ratio were increased significantly when compared with those in the control group. In patients with high glucose levels (>200 mg dl(-1)), ALP, GGT activities and CK-MB/CK ratio (p = 0.003, 0.001, 0.001) were increased significantly when compared with those in the control group. Glucose, which was added to serum in different concentrations in vitro, did not directly affect enzyme activities such as ALP, GGT and CK. We concluded that increased glucose levels could damage the liver and the heart muscle cells. Monitoring of blood glucose levels is a more valuable parameter than monitoring HbA1c in the momentary evaluation of diabetes. Copyright (C) 2011 John Wiley & Sons, Ltd.en_US
dc.identifier.citationEvliyaoğlu, O., Kıbrıslı, E., Yıldırım, Y., Gökalp, O. ve Çolpan, L. (2011). Routine enzymes in the monitoring of type 2 diabetes mellitus. Cell Biochemistry and Function, 29(6), 506-512.
dc.identifier.doi10.1002/cbf.1779
dc.identifier.endpage512en_US
dc.identifier.issn0263-6484
dc.identifier.issn1099-0844
dc.identifier.issue6en_US
dc.identifier.pmid21735456
dc.identifier.scopus2-s2.0-80051666045
dc.identifier.scopusqualityQ2
dc.identifier.startpage506en_US
dc.identifier.urihttps://doi.org/10.1002/cbf.1779
dc.identifier.urihttps://hdl.handle.net/11468/14007
dc.identifier.urihttps://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/cbf.1779
dc.identifier.volume29en_US
dc.identifier.wosWOS:000294267100009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorEvliyaoğlu, Osman
dc.institutionauthorKıbrıslı, Erkan
dc.institutionauthorGökalp, Osman
dc.institutionauthorÇolpan, Leyla
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofCell Biochemistry and Function
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectType 2 Diabetesen_US
dc.subjectEnzymesen_US
dc.subjectCk-Mb/Cken_US
dc.subjectAlpen_US
dc.subjectGgten_US
dc.titleRoutine enzymes in the monitoring of type 2 diabetes mellitusen_US
dc.titleRoutine enzymes in the monitoring of type 2 diabetes mellitus
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Routine enzymes in the monitoring of type 2 diabetes mellitus.pdf
Boyut:
211.51 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu