Routine enzymes in the monitoring of type 2 diabetes mellitus

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Tarih

2011

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Wiley

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

We examined the relationships of glucose and HbA1c levels with the routinely screened serum enzyme activities in type 2 diabetes mellitus, and we designed an in vitro study to evaluate the direct effect of glucose levels on enzyme activities. The study was performed on a consecutive series of outpatients with type 2 diabetes who were followed up at Dicle University Medical Faculty Hospital from May 2009 to May 2010 for the first time. Effects of aspartate transaminase, aminotransferase, gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) activities, glucose and HbA1c levels and in vitro glucose (492, 287, 184, 131, 82 mg dl(-1), respectively) on enzymes were determined. The patients were categorized on the basis of glucose and HbA1c levels and grouped according to a range of values. In patients with high HbA1c levels (>10.1%), ALP, GGT activities and creatine kinase (CK)-MB/CK (p = 0.008, 0.026, 0.014) ratio were increased significantly when compared with those in the control group. In patients with high glucose levels (>200 mg dl(-1)), ALP, GGT activities and CK-MB/CK ratio (p = 0.003, 0.001, 0.001) were increased significantly when compared with those in the control group. Glucose, which was added to serum in different concentrations in vitro, did not directly affect enzyme activities such as ALP, GGT and CK. We concluded that increased glucose levels could damage the liver and the heart muscle cells. Monitoring of blood glucose levels is a more valuable parameter than monitoring HbA1c in the momentary evaluation of diabetes. Copyright (C) 2011 John Wiley & Sons, Ltd.

Açıklama

Anahtar Kelimeler

Type 2 Diabetes, Enzymes, Ck-Mb/Ck, Alp, Ggt

Kaynak

Cell Biochemistry and Function

WoS Q Değeri

Q3

Scopus Q Değeri

Q2

Cilt

29

Sayı

6

Künye

Evliyaoğlu, O., Kıbrıslı, E., Yıldırım, Y., Gökalp, O. ve Çolpan, L. (2011). Routine enzymes in the monitoring of type 2 diabetes mellitus. Cell Biochemistry and Function, 29(6), 506-512.