Identifying phenolics by UPLC–MS/MS in some Prangos Lindl. species and ?-glucosidase inhibitory activities

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dc.authorid0000-0002-7482-0429en_US
dc.authorid0000-0003-3373-4759en_US
dc.authorid0000-0001-6030-6931en_US
dc.authorid0000-0002-8006-2054en_US
dc.authorid0000-0002-4090-7227en_US
dc.contributor.authorÖnder, Alev
dc.contributor.authorGülmez, Nazif
dc.contributor.authorBaran, Merve Yüzbaşıoğlu
dc.contributor.authorUz, Ayşe Kuruüzüm
dc.contributor.authorTrandifilova, Antoanetta
dc.contributor.authorÇakır, Oğuz
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.contributor.authorKoç, Ahsen Sevde Çınar
dc.date.accessioned2024-01-25T06:12:18Z
dc.date.available2024-01-25T06:12:18Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Atatürk Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractDiabetes mellitus is a chronic metabolic disorder associated with biochemical, physiological, and pathological changes in the liver and characterized by some deficiencies in insulin secretion or insulin action. Prangos Lindl. species are important plants used as spice and medicine in Asian countries, including Türkiye. This study first aimed to evaluate the antidiabetic potential of the aerial parts of the 5 different Prangos species (Apiaceae) collected from various locations to discover and identify bioactive phenolic components. The results revealed that the methanolic extract of P. heyniae exhibited the highest activity against α-glucosidase inhibition compared to the other Prangos species (IC50 = 458.54 ± 5.62 μg/mL). For this reason, the active species P. heyniae (an endemic species) was subjected to UPLC–MS/MS to evaluate the possible active phenolic components. The results showed that 53 phenolic compounds were correctly screened, 21 were precisely determined by UPLC–MS/MS in P. heyniae. Therefore, it was concluded that the aerial parts of P. heyniae might have therapeutic potential for hyperglycemia due to its phenolic compounds. Moreover, quinic acid (3.66%), chlorogenic acid (2.35%), rutin (2.96%), and hesperidin (0.79%) might be potential markers of the methanolic extract of P. heyniae. In the end, this study provides comprehensive knowledge regarding the phenolic profile of P. heyniae related to antidiabetic activity for the first time in this study.en_US
dc.identifier.citationÖnder, A., Gülmez, N., Baran, M. Y., Uz, A. K., Trandifilova, A., Koç, A. S. Ç. ve diğerleri. (2023). Identifying phenolics by UPLC–MS/MS in some Prangos Lindl. species and α-glucosidase inhibitory activities. Journal of Pharmaceutical and Biomedical Analysis, 236, 1-7.en_US
dc.identifier.doi10.1016/j.jpba.2023.115733
dc.identifier.endpage7en_US
dc.identifier.issn0731-7085
dc.identifier.pmid37788526
dc.identifier.scopus2-s2.0-85173957737
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.trdizinidTRDizinIdYok
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0731708523005022?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11468/13272
dc.identifier.volume236en_US
dc.identifier.wosWOS:001094520100001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorÇakır, Oğuz
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofJournal of Pharmaceutical and Biomedical Analysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntidiabeticen_US
dc.subjectApiaceaeen_US
dc.subjectPhenolicsen_US
dc.subjectPrangosen_US
dc.subjectPrangos heyniaeen_US
dc.subjectα-Glucosidaseen_US
dc.titleIdentifying phenolics by UPLC–MS/MS in some Prangos Lindl. species and ?-glucosidase inhibitory activitiesen_US
dc.titleIdentifying phenolics by UPLC–MS/MS in some Prangos Lindl. species and ?-glucosidase inhibitory activities
dc.typeArticleen_US

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