The effect of rosmarinic acid on deformities occurring in brain tissue by craniectomy method. Histopathological evaluation of iba-1 and gfap expressions

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dc.authorid0000-0002-2353-1184en_US
dc.authorid0000-0001-7317-5467en_US
dc.contributor.authorÖzevren, Hüseyin
dc.contributor.authorDeveci, Engin
dc.contributor.authorTuncer, Cudi Mehmet
dc.date.accessioned2021-08-17T06:09:11Z
dc.date.available2021-08-17T06:09:11Z
dc.date.issued2020en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalıen_US
dc.description.abstractPurpose: To investigate the role of Rosmarinic acid (RA) in the prevention of traumatic brain inand the immunohistochemical analysis of IBA-1 and GFAP expressions.Methods: Healthy male rats were randomly divided into 3 groups consisting of 10 rats. Groups were as follows; control group, traumatic brain injury (TBI) group, and TBI+RA group. After traumatic brain injury, blood samples were taken from the animals and analyzed with various biochemical markers. And then IBA-1 and GFAP expressions were evaluated immunohistochemically.Results: Significant results were obtained in all biochemical parameters between groupImmunohistochemical sections showed IBA-1 not only in microglia and macrophage activity but alsin degenerative neurons in blood vessel endothelial cells. However, GFAP reaction and post-traumatirosmarinic acid administration showed positive expression in astrocytes with regular structure arounthe blood vessel.Conclusion: Rosmarinic acid in blood vessel endothelial cells showed that preserving the integrity of astrocytic structure in the blood brain barrier may be an important antioxidant.en_US
dc.identifier.citationÖzevren, H., Deveci, E. ve Tuncer, C. M. (2020). The effect of rosmarinic acid on deformities occurring in brain tissue by craniectomy method. Histopathological evaluation of iba-1 and gfap expressions. Acta Cirurgica Brasileira, 35(4), 1-10.en_US
dc.identifier.doi10.1590/s0102-865020200040000006
dc.identifier.endpage10en_US
dc.identifier.issn0102-8650
dc.identifier.issue4en_US
dc.identifier.pmid32578724
dc.identifier.scopus2-s2.0-85087028486
dc.identifier.scopusqualityQ2
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.scielo.br/j/acb/a/hnnxfWwKrN7nhqfrf5JVqVg/?lang=en
dc.identifier.urihttps://hdl.handle.net/11468/7336
dc.identifier.volume35en_US
dc.identifier.wosWOS:000543690200001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzevren, Hüseyin
dc.institutionauthorDeveci, Engin
dc.institutionauthorTuncer, Cudi Mehmet
dc.language.isotren_US
dc.publisherSociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgiaen_US
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBrain Injuriesen_US
dc.subjectTraumaticen_US
dc.subjectGlial fibrillary acidic proteinen_US
dc.subjectRaten_US
dc.subjectRosmarinic aciden_US
dc.titleThe effect of rosmarinic acid on deformities occurring in brain tissue by craniectomy method. Histopathological evaluation of iba-1 and gfap expressionsen_US
dc.titleThe effect of rosmarinic acid on deformities occurring in brain tissue by craniectomy method. Histopathological evaluation of iba-1 and gfap expressions
dc.typeArticleen_US

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