Relation between severity of injury and the early activation of interleukins in multiple-injured patients
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Tarih
2005
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Karger
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of this study was to evaluate the relation between severity of injury and the early activation of interleukins in multiple-injured patients. Ninety-nine patients with multiple injuries were included in this prospective study. Plasma levels of interleukin (IL)-1, IL-2, IL-6, IL-8 and TNF-alpha were measured. Injury Severity Score ( ISS), Revised Trauma Score (RTS), Glasgow Coma Score (GCS) and the Acute Physiology and Chronic Health Evaluation II (APACHE- II) were all recorded. Of the 99 patients, 82 were male and 17 were female. The mean age was 26.6 +/- 20.7 years. The mortality rate for this series was 17%. Patients who died from trauma exhibited a significant increase for IL-2, IL-6 and IL-8 in comparison with patients who survived. Significant differences for ISS, RTS and GCS were found between survivors and non-survivors. Values in all patients with ISS 1 16 were increased and these increases were significant for IL-6 and IL-2. These data show that the initial increase of IL-2, IL-6 and IL-8 might predict the patients with a high possibility of mortality and a significant increase of IL-2 and IL-6 in patients with ISS > 16 might be used in a new developed trauma score combined with ISS as an indicator for the injury severity. Copyright (C) 2005 S. Karger AG, Basel.
Açıklama
40th Congress of the European-Society-for-Surgical-Research -- MAY 25-28, 2005 -- Konya, TURKEY
Anahtar Kelimeler
Multiple-Injured Patients, Cytokines, Mortality
Kaynak
European Surgical Research
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
37
Sayı
6
