Effect of intraperitoneal etanercept on oxidative stress in rats with peritonitis

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dc.contributor.authorYıldırım, Yaşar
dc.contributor.authorCellad, Esma Gülsüm
dc.contributor.authorKara, Ali Veysel
dc.contributor.authorYilmaz, Zülfükar
dc.contributor.authorKadiroğlu, Ali Kemal
dc.contributor.authorBahadır, Mehmet Veysi
dc.contributor.authorGül, Mesut
dc.date.accessioned2024-04-24T17:12:16Z
dc.date.available2024-04-24T17:12:16Z
dc.date.issued2016
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalıen_US
dc.description.abstractOur aim was to evaluate effect of etanercept on oxidative stress parameters in rats with experimental peritonitis and investigate the availability of etanercept usage in the treatment of peritonitis in the future. Twenty-eight rats were divided into four groups as control (group 1), peritonitis (group 2), peritonitis + cefazolin sodium (group 3), and peritonitis + cefazolin sodium + etanercept (group 4). Peritoneal tissue and blood samples were taken from all of the rats for histopathological and biochemical examination. The oxidative stress parameters were examined in blood and tissue samples. It was observed that rats with peritonitis benefit from cefazolin sodium treatment. Evaluating the effectiveness of etanercept was our main objective for this study. In this perspective, we compared group 3 and group 4 and found statistically significant decreases in oxidative parameters and statistically significant increases in antioxidants in serum and tissue samples in group 4. It is observed that there was a significant contribution of etanercept on biochemical and also histopathological results. As a result, the TNF-alpha inhibitor, etanercept, in addition to antibiotics given in the early treatment of peritonitis results in more significant improvement of histopathological and oxidative parameters as compared to antibiotics alone.en_US
dc.description.sponsorshipDicle University Coordination of Scientific Research Projects [13-TF-34]en_US
dc.description.sponsorshipThe authors experimental study was conducted in Dicle University by Professor Dr. Sabahattin Payzin at the Health Science Research and Application Center (DUSAM) with the approval of ethical committee for animal experiments. The project was supported by Dicle University Coordination of Scientific Research Projects (Project no. 13-TF-34).en_US
dc.identifier.citationYıldırım, Y., Cellad, E. G., Kara, A. V., Yılmaz, Z., Kadiroğlu, A. K., Bahadır, M. V. ve diğerleri. (2016). Effect of intraperitoneal etanercept on oxidative stress in rats with peritonitis. Oxidative Medicine and Cellular Longevity, 2016, 1-7.
dc.identifier.doi10.1155/2016/9418468
dc.identifier.issn1942-0900
dc.identifier.issn1942-0994
dc.identifier.pmid27066189
dc.identifier.scopus2-s2.0-84962840872
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1155/2016/9418468
dc.identifier.urihttps://hdl.handle.net/11468/17913
dc.identifier.volume2016en_US
dc.identifier.wosWOS:000375642600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofOxidative Medicine and Cellular Longevity
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keyword]en_US
dc.titleEffect of intraperitoneal etanercept on oxidative stress in rats with peritonitisen_US
dc.titleEffect of intraperitoneal etanercept on oxidative stress in rats with peritonitis
dc.typeArticleen_US

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