Effect of intraperitoneal etanercept on oxidative stress in rats with peritonitis
Yükleniyor...
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Hindawi Ltd
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Our aim was to evaluate effect of etanercept on oxidative stress parameters in rats with experimental peritonitis and investigate the availability of etanercept usage in the treatment of peritonitis in the future. Twenty-eight rats were divided into four groups as control (group 1), peritonitis (group 2), peritonitis + cefazolin sodium (group 3), and peritonitis + cefazolin sodium + etanercept (group 4). Peritoneal tissue and blood samples were taken from all of the rats for histopathological and biochemical examination. The oxidative stress parameters were examined in blood and tissue samples. It was observed that rats with peritonitis benefit from cefazolin sodium treatment. Evaluating the effectiveness of etanercept was our main objective for this study. In this perspective, we compared group 3 and group 4 and found statistically significant decreases in oxidative parameters and statistically significant increases in antioxidants in serum and tissue samples in group 4. It is observed that there was a significant contribution of etanercept on biochemical and also histopathological results. As a result, the TNF-alpha inhibitor, etanercept, in addition to antibiotics given in the early treatment of peritonitis results in more significant improvement of histopathological and oxidative parameters as compared to antibiotics alone.
Açıklama
Anahtar Kelimeler
[No Keyword]
Kaynak
Oxidative Medicine and Cellular Longevity
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
2016
Sayı
Künye
Yıldırım, Y., Cellad, E. G., Kara, A. V., Yılmaz, Z., Kadiroğlu, A. K., Bahadır, M. V. ve diğerleri. (2016). Effect of intraperitoneal etanercept on oxidative stress in rats with peritonitis. Oxidative Medicine and Cellular Longevity, 2016, 1-7.
