Comparison of the anti-diabetic and nephroprotective activities of vitamin E, metformin, and Nigella sativa oil on kidney in experimental diabetic rats

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dc.authorid0000-0002-0556-9031en_US
dc.authorid0000-0001-6251-6529en_US
dc.authorid0000-0002-1693-6378en_US
dc.authorid0000-0002-9988-9385en_US
dc.contributor.authorAyaz, Hayat
dc.contributor.authorKaya, Seval
dc.contributor.authorŞeker, Uğur
dc.contributor.authorNergiz, Yusuf
dc.date.accessioned2023-10-26T07:13:34Z
dc.date.available2023-10-26T07:13:34Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractObjective(s): In this study, we aimed to evaluate and compare the nephroprotective and possible anti-diabetic effects of vitamin E, metformin, and Nigella sativa. Materials and Methods: Thirty male Wistar Albino rats were randomly divided into control, experimental diabetes (DM), vitamin E + DM, Metformin + DM, and N. sativa + DM. For experimental diabetes induction, IP 45 mg/kg streptozotocin was administered. Rats in vitamin E + DM, Metformin + DM, and N. sativa + DM received 100 mg/kg vitamin E, 100 mg/kg metformin, and 2.5 ml/kg N. sativa oil for 56 days. After the experiment, all animals were sacrificed, and blood and kidney samples were collected. Results: The blood urea level of the DM group was significantly higher (P[removed]0.05) but significantly different from the DM group (P[removed]0.05). Bcl-2 immunopositivity density was highest in the N. sativa group, similar to the control group in terms of percentile area (P>0.05). Conclusion: When all three treatment methods were compared in terms of their effectiveness in alleviating DM and DN, it was determined that the most successful result was obtained with N. sativa oil.en_US
dc.identifier.citationAyaz, H., Kaya, S., Şeker, U. ve Nergiz, Y. (2023). Comparison of the anti-diabetic and nephroprotective activities of vitamin E, metformin, and Nigella sativa oil on kidney in experimental diabetic rats. Iranian Journal of Basic Medical Sciences, 26(4), 395-399.en_US
dc.identifier.doi10.22038/IJBMS.2023.68051.14876
dc.identifier.endpage399en_US
dc.identifier.issn2008-3866
dc.identifier.issue4en_US
dc.identifier.pmid37009001
dc.identifier.scopus2-s2.0-85153327833
dc.identifier.scopusqualityQ2
dc.identifier.startpage395en_US
dc.identifier.urihttps://ijbms.mums.ac.ir/article_21836.html
dc.identifier.urihttps://hdl.handle.net/11468/12945
dc.identifier.volume26en_US
dc.identifier.wosWOS:000995870300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAyaz, Hayat
dc.institutionauthorNergiz, Yusuf
dc.language.isoenen_US
dc.publisherMashhad University of Medical Sciencesen_US
dc.relation.ispartofIranian Journal of Basic Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptosisen_US
dc.subjectDiabetes mellitusen_US
dc.subjectKidneyen_US
dc.subjectMetforminen_US
dc.subjectNigella sativaen_US
dc.subjectVitamin Een_US
dc.titleComparison of the anti-diabetic and nephroprotective activities of vitamin E, metformin, and Nigella sativa oil on kidney in experimental diabetic ratsen_US
dc.titleComparison of the anti-diabetic and nephroprotective activities of vitamin E, metformin, and Nigella sativa oil on kidney in experimental diabetic rats
dc.typeArticleen_US

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