Effect of ellagic acid on damage caused by hepatic ischemia reperfusion in rats

Basit Öğe Kaydı
dc.authorid0000-0002-6384-9146en_US
dc.contributor.authorDurgun, Cemalettin
dc.contributor.authorAşır, Fırat
dc.date.accessioned2024-01-10T06:54:54Z
dc.date.available2024-01-10T06:54:54Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractOBJECTIVE: Ischemia (I) causes lack of oxygen delivery to the tissues, leading to hypoxia and cellular damage. Reperfusion (R) is the re-blooded of the tissue; however, it may cause more tissue damage than ischemia alone in some cases. During IR, number of free radicals and metabolic by-products increases. To prevent this, cellular antioxidant system is activated but it may not be enough to restore the cellular activities. The aim of this study was to investigate the potential protective effect of Ellagic Acid on damage caused by hepatic IR in rats. MATERIALS AND METHODS: Thirty rats were divided into three groups: (1) Sham group - no drug administration but only midline laparotomy was performed in the abdomen; (2) Ischemia-Reperfusion (IR) group - ischemia was applied for 1 hour by sealing the portal vein and hepatic artery, then vessels were reperfused for 6 hours; (3) IR+Elagic Acid (EA) group - after IR, 10 mg/kg of EA was given intraperitonially to the rats once a day for 28 days. Oxidative stress markers were analyzed by blood collection. Hepatic tissues were processed for histological and immunohistochemical analysis. RESULTS: MDA level and MPO activity were increased and GSH content was decreased after IR group was compared to sham group. After EA treatment, these values were improved in IR+EA group. IR caused hepatocyte degeneration, sinusoidal dilatation, leukocyte infiltration and disintegrity of hepatic tissue. EA administration improved histopathology after IR. IR injury increased TNF-α and Caspase-9 expression in hepatocytes and vascular endothelial cells in IR group; however, both decreased in EA-received group. CONCLUSIONS: Ellagic Acid may reduce oxidative stress level and prevent induction of inflammation and cell death against hepatic IR.en_US
dc.identifier.citationDoğru, C. ve Aşır, F. (2022). Effect of ellagic acid on damage caused by hepatic ischemia reperfusion in rats. European Review for Medical and Pharmacological Sciences, 26(22), 8209-8215.en_US
dc.identifier.doi10.26355/eurrev_202211_30352
dc.identifier.endpage8215en_US
dc.identifier.issn1128-3602
dc.identifier.issue22en_US
dc.identifier.pmid36459004
dc.identifier.scopus2-s2.0-85143270793
dc.identifier.scopusqualityQ2
dc.identifier.startpage8209en_US
dc.identifier.urihttps://www.europeanreview.org/article/30352
dc.identifier.urihttps://hdl.handle.net/11468/13167
dc.identifier.volume26en_US
dc.identifier.wosWOS:000893582600004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAşır, Fırat
dc.language.isoenen_US
dc.publisherVerduci Editore s.r.len_US
dc.relation.ispartofEuropean Review for Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCaspase-9en_US
dc.subjectEllagicaciden_US
dc.subjectIschemia-Reperfusionen_US
dc.subjectTNF-αen_US
dc.titleEffect of ellagic acid on damage caused by hepatic ischemia reperfusion in ratsen_US
dc.titleEffect of ellagic acid on damage caused by hepatic ischemia reperfusion in rats
dc.typeArticleen_US

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