Role of SOX9 and Hif-1? expression in placentas of patients with HELLP

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dc.authorid0000-0001-8286-2824en_US
dc.authorid0000-0002-7577-7012en_US
dc.authorid0000-0002-2353-1184en_US
dc.contributor.authorAkalın, Senem Alkan
dc.contributor.authorÖcal, Ece
dc.contributor.authorDeveci, Engin
dc.date.accessioned2024-03-04T13:26:20Z
dc.date.available2024-03-04T13:26:20Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractPurpose: In this study, we investigated the immunohistochemical staining of SRY-box transcription factor 9 (SOX9) and Hif-1α expression in placentas of pregnant woman with hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome. Methods: Placentas of 20 normotensive and 20 women with HELLP syndrome were processed for routine histological tissue processing. The biochemical and clinical parameters of patients were recorded. Placentas were stained with hematoxylin-eosin and SOX9 and Hif-1α immunostaining. Results: Normotensive placentas showed normal histology of placenta, however placentas of HELLP syndrome showed intense thrombosis, thinning of the villi membrane and vascular dilatation. In placentas of normotensive patients, SOX9 reaction was immunohistochemically negative, however placentas of HELLP group showed SOX9 expression in decidual cells, and syncytial regions of floating villi and inflammatory cells. In placentas of normotensive patients, Hif-1α reaction was mainly negative in vessels and connective tissue cells. Placentas of HELLP group showed increased Hif-1α expression in decidual cell and especially inflammatory cells in the maternal region. Conclusion: Hif-1α and SOX9 proteins can be used as a marker to show severity of preeclampsia and regulation of cell proliferation and angiogenesis during placental development.en_US
dc.identifier.citationAkalın, S. A., Öcal, E. ve Deveci, E. (2023). Role of SOX9 and Hif-1α expression in placentas of patients with HELLP. Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia, 38, 1-9.en_US
dc.identifier.doi10.1590/acb388023
dc.identifier.endpage9en_US
dc.identifier.issn0102-8650
dc.identifier.pmid37878989
dc.identifier.scopus2-s2.0-85174932732
dc.identifier.scopusqualityQ2
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.scielo.br/j/acb/a/fQddpLQXcX5vLqQfMRN3fGf/?lang=en
dc.identifier.urihttps://hdl.handle.net/11468/13504
dc.identifier.volume38en_US
dc.identifier.wosWOS:001093285600001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDeveci, Engin
dc.language.isoenen_US
dc.publisherSociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgiaen_US
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAngiogenesisen_US
dc.subjectPathologicen_US
dc.subjectHistologyen_US
dc.subjectPlacentaen_US
dc.subjectPre-eclampsiaen_US
dc.titleRole of SOX9 and Hif-1? expression in placentas of patients with HELLPen_US
dc.titleRole of SOX9 and Hif-1? expression in placentas of patients with HELLP
dc.typeArticleen_US

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