Biomarker insights: Evaluation of presepsin, apelin, and irisin levels in cutaneous leishmaniasis

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dc.authorid0000-0003-2906-8589
dc.authorid0000-0003-3742-6075
dc.authorid0000-0003-4577-4475
dc.contributor.authorErkan, Revşa Evin Canpolat
dc.contributor.authorTekin, Recep
dc.contributor.authorSula, Bilal
dc.date.accessioned2025-02-22T14:08:40Z
dc.date.available2025-02-22T14:08:40Z
dc.date.issued2024
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.description.abstractBackground/Objectives: Cutaneous leishmaniasis (CL) is a skin disease caused by Leishmania parasites. Presepsin, irisin, and apelin are biomarkers that are involved in the inflammatory response. The aim of this study was to investigate the association between serum levels of specific biomarkers, such as presepsin, apelin, and irisin, and the clinical features, location, number, and size of lesions in patients with CL. Methods: This study is a single-centre, prospective cohort study involving a total of 30 patients with skin lesions compatible with CL and 30 healthy matched controls. Age, sex, type of skin lesion, location of skin lesion, number of skin lesions, and diameter of skin lesions were recorded. The levels of presepsin, irisin, and apelin measured in the blood samples of the patient group were analysed in comparison to those in the healthy control group. Results: The findings revealed that presepsin levels were significantly elevated in the patient group compared to the controls (p = 0.000). However, no statistically significant differences were observed between the groups for irisin and apelin levels (p-values 0.096 and 0.836, respectively). A negative correlation was identified between presepsin levels and the number of skin lesions, the diameter of the largest lesion, and the total diameter of the lesions (p = 0.000). Conclusions: It appears that measuring presepsin levels in patients with CL may be beneficial. Presepsin has the potential to serve as a prognostic marker in CL, offering significant benefits in guiding clinicians in assessing disease progression and response to treatment.en_US
dc.description.sponsorshipthe Dicle University Scientific Research Projects Commission [TIP.20.011]; Dicle University Scientific Research Projects Commissionen_US
dc.description.sponsorshipThis research was funded by the Dicle University Scientific Research Projects Commission, grant number TIP.20.011.en_US
dc.identifier.citationErkan, R. E. C., Tekin, R. ve Sula, B. (2024). Biomarker insights: Evaluation of presepsin, apelin, and irisin levels in cutaneous leishmaniasis. Diagnostics, 14(24), 1-8.
dc.identifier.doi10.3390/diagnostics14242869
dc.identifier.issn2075-4418
dc.identifier.issue24en_US
dc.identifier.pmid39767230en_US
dc.identifier.scopus2-s2.0-85213408856en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3390/diagnostics14242869
dc.identifier.urihttps://hdl.handle.net/11468/29559
dc.identifier.volume14en_US
dc.identifier.wosWOS:001384937900001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErkan, Revşa Evin Canpolat
dc.institutionauthorTekin, Recep
dc.institutionauthorSula, Bilal
dc.institutionauthorid0000-0003-2906-8589
dc.institutionauthorid0000-0003-3742-6075
dc.institutionauthorid0000-0003-4577-4475
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofDiagnosticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectCutaneous leishmaniasisen_US
dc.subjectPresepsinen_US
dc.subjectApelinen_US
dc.subjectIrisinen_US
dc.titleBiomarker insights: Evaluation of presepsin, apelin, and irisin levels in cutaneous leishmaniasisen_US
dc.typeArticleen_US

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