Identification of major phenolic compounds of Aloe vera and its protective effect on ovaries under oxidative stress in diabetic rats

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dc.authorid0000-0002-0191-3245en_US
dc.authorid0000-0002-1693-6378en_US
dc.authorid0000-0002-0039-5597en_US
dc.authorid0000-0002-9241-2496en_US
dc.authorid0000-0002-7713-3704en_US
dc.authorid0000-0001-6453-0033en_US
dc.contributor.authorKurt, Serdal
dc.contributor.authorŞeker, Uğur
dc.contributor.authorYazlık, Murat Onur
dc.contributor.authorHürkul, Muhammed Mesud
dc.contributor.authorEr, Engin
dc.contributor.authorSöker, Sevda
dc.date.accessioned2023-07-03T08:38:05Z
dc.date.available2023-07-03T08:38:05Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractThe study investigated the major phenolic compounds of Aloe vera leaf (AVL) by the high-performance liquid chromatography (HPLC) method, and its protective effect on ovaries under oxidative stress of streptozotocin- induced diabetic rats. The study was conducted on control (untreated healthy rats; C), diabetes (untreated diabetic rats; D) and diabetes+A. vera treatment (diabetic rats treated with A. vera; D+A) groups. D+A group was given an ethanolic extract of A. vera (300 mg/kg) for 14 days. Major phenolic compounds of AVL were chlorogenic acid and rutin. alanine transaminase (ALT) and aspartate aminotransferase (AST) levels increased in D group compared to others groups (P<0.01). Alkaline phosphatase (ALP) and albumin levels were lower and higher in the C group than in other groups, respectively (P<0.01). In the D group compared to other groups, oxidative stress index (OSI) and total oxidant status levels increased, while total antioxidant status level decreased in both ovarian tissues and blood (P<0.01). Preantral and antral follicle counts decreased in the D group according to other groups (P<0.01) and atretic follicle count increased (P<0.05). Proliferating cell nuclear antigen (PCNA) expression level (P<0.01), and B-cell lymphoma-2-associated-X- protein (Bax; P<0.01) and tumor necrosis factor-alpha (TNF-α) expression levels (P<0.05) decreased and increased in group D according to other groups, respectively. In conclusion, treatment with AVL decreased OSI, improved follicular dynamics, and restored Bax, TNF-α and PCNA expression in diabetic rats.en_US
dc.identifier.citationKurt, S., Şeker, U., Yazlık, M. O., Hürkul, M. M., Er, E. ve Söker, S. (2023). Identification of major phenolic compounds of Aloe vera and its protective effect on ovaries under oxidative stress in diabetic rats. Journal of Research in Pharmacy, 27(2), 652-664.en_US
dc.identifier.doi10.29228/jrp.348
dc.identifier.endpage664en_US
dc.identifier.issn2630-6344
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85151377901
dc.identifier.scopusqualityQ3
dc.identifier.startpage652en_US
dc.identifier.trdizinid1177576
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1177576
dc.identifier.urihttps://hdl.handle.net/11468/12143
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1177576
dc.identifier.volume27en_US
dc.identifier.wosWOS:000990531300006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorSöker, Sevda
dc.language.isoenen_US
dc.relation.ispartofJournal of Research in Pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleIdentification of major phenolic compounds of Aloe vera and its protective effect on ovaries under oxidative stress in diabetic ratsen_US
dc.titleIdentification of major phenolic compounds of Aloe vera and its protective effect on ovaries under oxidative stress in diabetic rats
dc.typeArticleen_US

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