Effects of nimodipine and nigella sativa on oxidative stress and apoptosis in serum and brain tissue of rats with experimental head trauma

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dc.authorid0000-0003-4551-8439en_US
dc.authorid0000-0002-0876-6612en_US
dc.contributor.authorKamasak, Kağan
dc.contributor.authorBaşarslan, Kağan
dc.contributor.authorDağlı, Ahmet Turan
dc.contributor.authorÖgden, Mustafa
dc.contributor.authorAlabalık, Ulaş
dc.contributor.authorEkinci, Adnan
dc.contributor.authorCeviz, Adnan
dc.date.accessioned2021-04-14T08:16:42Z
dc.date.available2021-04-14T08:16:42Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi PatolojiAna Bilim Dalıen_US
dc.descriptionWOS:000610243400002
dc.descriptionPMID: 31124573
dc.description.abstractAIM: To investigate whether Nimodipine (N) and Nigella sativa (NS) oil have protective, antioxidant effects in brain injury caused by experimental head trauma. MATERIAL and METHODS: Fifty albino Wistar rats were randomly divided into 5 groups that underwent experimental head trauma. Oxidative parameters were compared in the serum and brain tissue of the different groups. In addition, apoptosis and caspase-3 immunoreactivity were evaluated by histopathological examination. RESULTS: Serum total antioxidant status (TAS) levels were significantly increased in N and N+NS groups when compared with controls (p=0.001, p<0.01). Tissue TAS levels were significantly higher in the NS and N+NS groups compared to controls (p=0.001, p<0.01). Total oxidant status levels in the brain tissue were significantly higher in the NS group than in the control group (p=0.021). CONCLUSION: N and NS were shown to significantly reduce the occurrence of oxidative stress in secondary brain injury due to head trauma. We also found that apoptosis levels decreased in response to N, NS and N+NS treatments after head trauma.en_US
dc.identifier.citationKamasak, K., Başaran, K., Dağlı, A.T., Ögden, M., Alabalık, U., Ekinci, A. ve diğerleri. (2021). Effects of nimodipine and nigella sativa on oxidative stress and apoptosis in serum and brain tissue of rats with experimental head trauma. Turkish Neurosurgery, 31(1), 8-17.en_US
dc.identifier.doi10.5137/1019-5149.JTN.25523-19.3
dc.identifier.endpage17en_US
dc.identifier.issn1019-5149
dc.identifier.issue1en_US
dc.identifier.pmid31124573
dc.identifier.scopus2-s2.0-85089298668
dc.identifier.scopusqualityQ3
dc.identifier.startpage8en_US
dc.identifier.urihttp://turkishneurosurgery.org.tr/pdf/pdf_JTN_2422.pdf
dc.identifier.urihttps://hdl.handle.net/11468/6705
dc.identifier.volume31en_US
dc.identifier.wosWOS:000610243400002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAlabalık, Ulaş
dc.institutionauthorCeviz, Adnan
dc.language.isoenen_US
dc.publisherTurkish Neurosurgical Soc.en_US
dc.relation.ispartofTurkish Neurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCraniocerebral traumaen_US
dc.subjectNigella sativaen_US
dc.subjectNimodipineen_US
dc.subjectOxidative stressen_US
dc.subjectApoptosisen_US
dc.subjectRatsen_US
dc.titleEffects of nimodipine and nigella sativa on oxidative stress and apoptosis in serum and brain tissue of rats with experimental head traumaen_US
dc.titleEffects of nimodipine and nigella sativa on oxidative stress and apoptosis in serum and brain tissue of rats with experimental head trauma
dc.typeArticleen_US

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