A multicentre, multinational study of clinical characteristics and prognosis of hepatocellular carcinoma

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dc.authorid0000-0002-0929-3271en_US
dc.authorid0000-0003-2335-3354en_US
dc.contributor.authorDirican, Ahmet
dc.contributor.authorUncu, Doğan
dc.contributor.authorSekacheva, Marina
dc.contributor.authorArtaç, Mehmet
dc.contributor.authorAladashvil, Archil
dc.contributor.authorErdoğan, Atike
dc.contributor.authorKaplan, Muhammet
dc.date.accessioned2023-09-29T12:52:57Z
dc.date.available2023-09-29T12:52:57Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalıen_US
dc.description.abstractBackground: Hepatocellular carcinoma (HCC) is a significant health problem, and the associated mortality rate is increasing. Aim: We aimed to determine the clinical characteristics and prognosis for HCC in member countries of the OncoBridge Study Group. Methods: We recruited 630 patients diagnosed with HCC between 2013 and 2019 from 4 countries (Türkiye, Russia, Georgia, and Greece). Univariate and multivariate analyses were conducted to investigate clinical and laboratory prognostic factors. Receiver operating characteristic (ROC) analysis was used to determine the prognostic value of the neutrophil to lymphocyte ratio (NLR) and alpha-fetoprotein (AFP) value. Results: The 3 most common etiological factors were hepatitis B infection (39.7%), hepatitis C virus infection (17.0%) and non-alcoholic fatty liver disease (9.0%). Median overall survival for the whole group was 25 [95% confidence interval (CI): 15.7–34.2] months. Cut-off values for AFP and NLR were accepted as 200 ng/mL and 3.45, respectively. The area under the ROC curve values for AFP, NLR and NLR+AFP were 0.625 (95% CI: 0.547–0.704), 0.589 (95% CI: 0.512–0.667) and 0.657 (95% CI: 0.583–0.731). From the multivariate analysis, advanced tumour size, lymph node involvement and metastasis (TNM) stage, presence of cirrhosis, high AFP, and high NLR values were associated with poor survival. Conclusion: AFP, NLR, advanced TNM, and presence of cirrhosis may predict prognosis in patients with HCC. Studies involving more countries are needed to corroborate these findings.en_US
dc.identifier.citationDirican, A., Uncu, D., Sekacheva, M., Artaç, M., Aladashvil, A., Erdoğan, A. ve diğerleri. (2023). A multicentre, multinational study of clinical characteristics and prognosis of hepatocellular carcinoma. Eastern Mediterranean Health Journal, 29(6), 462-473.en_US
dc.identifier.doi10.26719/emhj.23.087en_US
dc.identifier.endpage473en_US
dc.identifier.issn1020-3397
dc.identifier.issue6en_US
dc.identifier.pmid37551758en_US
dc.identifier.scopus2-s2.0-85165867271en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage462en_US
dc.identifier.urihttps://applications.emro.who.int/EMHJ/V29/06/1020-3397-2023-2906-462-473-eng.pdf
dc.identifier.urihttps://hdl.handle.net/11468/12638
dc.identifier.volume29en_US
dc.identifier.wosWOS:001024778700006
dc.identifier.wosWOS:001024778700006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKaplan, Muhammet
dc.language.isoenen_US
dc.publisherWorld Health Organizationen_US
dc.relation.ispartofEastern Mediterranean Health Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGeorgiaen_US
dc.subjectGreeceen_US
dc.subjectHepatocellular carcinomaen_US
dc.subjectNeutrophil to lymphocyte ratioen_US
dc.subjectPrognosisen_US
dc.subjectRussiaen_US
dc.subjectTürkiyeen_US
dc.titleA multicentre, multinational study of clinical characteristics and prognosis of hepatocellular carcinomaen_US
dc.title.alternativeÉtude multicentrique et multinationale des caractéristiques cliniques et du pronostic du carcinome hépatocellulaireen_US
dc.typeArticleen_US

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